L3MBTL2抗体,Rabbit Polyclonal L3MBTL2 Antibody
  • L3MBTL2抗体,Rabbit Polyclonal L3MBTL2 Antibody
  • L3MBTL2抗体,Rabbit Polyclonal L3MBTL2 Antibody
  • L3MBTL2抗体,Rabbit Polyclonal L3MBTL2 Antibody

L3MBTL2抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-21
QQ交谈 微信洽谈

产品详情

中文名称:L3MBTL2抗体英文名称:Rabbit Polyclonal L3MBTL2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 5368 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: L3MBTL2
2025-05-21 L3MBTL2抗体 Rabbit Polyclonal L3MBTL2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 5368 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesL3MBT; H-l(3)mbt-l
WB Predicted band size79 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human L3MBTL2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

  •  

     

       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse thymus tissue lysate, Primary antibody: P10219(L3MBTL2 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 35 seconds    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P10219(L3MBTL2 Antibody) at dilution 1/70. (Original magnification: ×200)    


           

参考文献

以下是关于L3MBTL2抗体的3篇代表性文献及其摘要概括:

---

1. **"L3MBTL2 mediates silencing of repetitive DNA and regulates chromatin compaction"**

*Authors: Smith J, Doe R, Brown A (2018)*

摘要:该研究利用L3MBTL2特异性抗体进行染色质免疫沉淀(ChIP)实验,发现L3MBTL2通过识别组蛋白H4K20单甲基化修饰,靶向重复DNA区域并促进染色质凝缩,抑制转座元件和卫星序列的转录。

---

2. **"Structural basis for the interaction of L3MBTL2 with non-methylated histone peptides"**

*Authors: Chen X, Wang Y, Zhang L (2016)*

摘要:通过X射线晶体学结合抗体验证实验,揭示了L3MBTL2蛋白的MBT结构域与未甲基化组蛋白H3尾部结合的分子机制,表明其在基因沉默中可能通过竞争性抑制甲基化依赖的相互作用发挥作用。

---

3. **"Development and validation of a monoclonal antibody targeting the C-terminal domain of L3MBTL2"**

*Authors: Lee S, Kim T, Park H (2020)*

摘要:研究团队开发了一种靶向L3MBTL2 C端结构域的高效单克隆抗体,验证其在免疫荧光、Western blot和流式细胞术中的特异性,并应用于乳腺癌细胞中L3MBTL2亚细胞定位的动态分析。

---

4. **"L3MBTL2 depletion enhances somatic cell reprogramming through chromatin accessibility modulation"**

*Authors: García-Pérez R, Esteban-Cantos A, Rodríguez-Paredes M (2019)*

摘要:通过CRISPR/Cas9敲除和L3MBTL2抗体功能阻断实验,证明L3MBTL2通过维持异染色质稳定性抑制体细胞重编程,其缺失导致染色质开放性和多能性基因激活。

---

**备注**:以上文献信息为示例性内容,实际文献需通过PubMed或Google Scholar以关键词“L3MBTL2 antibody”或“L3MBTL2 function”检索获取。建议优先选择近5年发表于《Nature Structural & Molecular Biology》《Cell Reports》等期刊的研究。

       

背景信息

L3MBTL2 (Lethal(3)malignant brain tumor-like 2) is a chromatin-associated protein belonging to the MBT (malignant brain tumor) domain-containing protein family, which is implicated in epigenetic regulation. It recognizes and binds to mono- or dimethylated lysine residues on histones (e.g., H4K20me1/2), a feature linked to transcriptional repression and chromatin compaction. L3MBTL2 functions as a transcriptional repressor, often acting in concert with polycomb repressive complexes (PRCs) or other chromatin modifiers to regulate gene expression, genomic stability, and cellular differentiation. Its role in suppressing inappropriate transcription has been associated with tumor suppression, as dysregulation of L3MBTL2 is observed in certain cancers.

Antibodies targeting L3MBTL2 are essential tools for studying its localization, interactions, and mechanistic roles in chromatin biology. They are widely used in techniques like Western blotting, immunoprecipitation (IP), chromatin immunoprecipitation (ChIP), and immunofluorescence to investigate its involvement in DNA repair, cell cycle regulation, and developmental processes. Commercially available L3MBTL2 antibodies are typically validated for specificity against its unique MBT domains or other epitopes, enabling researchers to distinguish it from related family members (e.g., L3MBTL1 or MBTD1). Studies using these antibodies have highlighted L3MBTL2's contribution to maintaining heterochromatin integrity and its potential as a biomarker or therapeutic target in diseases marked by epigenetic dysregulation.

       
关键字: L3MBTL2抗体;L3MBTL2;L3MBTL2 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
询盘

L3MBTL2抗体—艾普蒂相关厂家报价

产品名称 价格   公司名称 报价日期
¥960.00
VIP10年
北京索莱宝科技有限公司
2026-02-06
询价
VIP4年
维百奥(北京)生物科技有限公司
2025-12-29
¥1800
VIP2年
费雪(杭州)医学研究有限公司
2026-01-05
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
内容声明:
以上所展示的信息由商家自行提供,内容的真实性、准确性和合法性由发布商家负责。 商家发布价格指该商品的参考价格,并非原价,该价格可能随着市场变化,或是由于您购买数量不同或所选规格不同而发生变化。最终成交价格,请咨询商家,以实际成交价格为准。请意识到互联网交易中的风险是客观存在的
主页 | 企业会员服务 | 广告业务 | 联系我们 | 旧版入口 | 中文MSDS | CAS Index | 常用化学品CAS列表 | 化工产品目录 | 新产品列表 |投诉中心
Copyright © 2008 ChemicalBook 京ICP备07040585号  京公海网安备110108000080号  All rights reserved.