HPCAL1抗体,Rabbit Polyclonal HPCAL1 Antibody
  • HPCAL1抗体,Rabbit Polyclonal HPCAL1 Antibody
  • HPCAL1抗体,Rabbit Polyclonal HPCAL1 Antibody
  • HPCAL1抗体,Rabbit Polyclonal HPCAL1 Antibody

HPCAL1抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-21
QQ交谈 微信洽谈

产品详情

中文名称:HPCAL1抗体英文名称:Rabbit Polyclonal HPCAL1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 5416 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: HPCAL1
2025-05-21 HPCAL1抗体 Rabbit Polyclonal HPCAL1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 5416 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesBDR1; HLP2; VILIP-3
WB Predicted band size22 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human HPCAL1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Rat brain tissue, Hela, HepG2 and A172 cell lysates, Primary antibody: P10286(HPCAL1 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 5 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P10286(HPCAL1 Antibody) at dilution 1/70. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P10286(HPCAL1 Antibody) at dilution 1/70. (Original magnification: ×200)    


           

参考文献

以下是关于HPCAL1抗体的3篇参考文献示例(注:文献为虚构示例,仅供格式参考):

1. **"HPCAL1 as a novel biomarker in Alzheimer's disease: Immunohistochemical analysis using a specific polyclonal antibody"**

*Authors: Smith A, et al. (2015)*

摘要:本研究开发了一种针对HPCAL1蛋白的多克隆抗体,验证了其在人脑组织中的特异性。通过免疫组化分析,发现HPCAL1在阿尔茨海默病患者海马区表达显著降低,提示其可能与神经元钙稳态失调相关。

2. **"Generation and characterization of a monoclonal antibody against human HPCAL1 for cancer research"**

*Authors: Brown C, et al. (2018)*

摘要:报道了一种新型抗HPCAL1单克隆抗体的制备与验证。该抗体在Western blot和免疫荧光中表现出高特异性,并用于检测胶质瘤细胞系中HPCAL1的异常高表达,为肿瘤靶向研究提供了工具。

3. **"HPCAL1 modulates neuronal calcium signaling: Insights from antibody-mediated protein interaction studies"**

*Authors: Garcia L, et al. (2017)*

摘要:利用HPCAL1抗体进行免疫共沉淀实验,揭示了HPCAL1与钙调蛋白的相互作用机制,证实其在调节神经元突触可塑性中的关键作用,为神经退行性疾病机制研究提供新方向。

       

背景信息

The HPCAL1 (Hippocalcin-like 1) antibody is a tool used to study the HPCAL1 protein, a member of the neuronal calcium sensor (NCS) family. HPCAL1. also known as Visinin-like 1 (VSNL1), is a calcium-binding protein enriched in neuronal and neuroendocrine tissues. It contains EF-hand motifs that enable calcium ion (Ca²⁺) binding, triggering conformational changes to regulate downstream signaling. HPCAL1 modulates Ca²⁺-dependent processes such as neurotransmitter release, synaptic plasticity, and cell survival, often by interacting with kinases, phosphatases, or membrane channels. Dysregulation of HPCAL1 has been linked to neurological disorders (e.g., Alzheimer’s disease) and cancers, where it may influence tumor progression or apoptosis resistance.

The HPCAL1 antibody is widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect HPCAL1 expression, localization, and post-translational modifications in research models. Its specificity is validated using knockout controls or siRNA-mediated silencing. Studies leveraging this antibody have explored HPCAL1's role in neuronal development, neurodegenerative pathways, and cancer biology. Commercial antibodies are typically raised against epitopes in conserved regions, often in rodents or humans. Researchers prioritize antibodies with high affinity and minimal cross-reactivity to related NCS proteins (e.g., neurocalcin, hippocalcin) to ensure accurate results in both qualitative and quantitative analyses.

       
关键字: HPCAL1抗体;HPCAL1;HPCAL1 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
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