MARCKSL1抗体,Rabbit Polyclonal MARCKSL1 Antibody
  • MARCKSL1抗体,Rabbit Polyclonal MARCKSL1 Antibody
  • MARCKSL1抗体,Rabbit Polyclonal MARCKSL1 Antibody
  • MARCKSL1抗体,Rabbit Polyclonal MARCKSL1 Antibody

MARCKSL1抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-21
QQ交谈 微信洽谈

产品详情

中文名称:MARCKSL1抗体英文名称:Rabbit Polyclonal MARCKSL1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 5419 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: MARCKSL1
2025-05-21 MARCKSL1抗体 Rabbit Polyclonal MARCKSL1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 5419 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesF52; MLP; MRP; MLP1; MACMARCKS
WB Predicted band size20 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human MARCKSL1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: RAW264.7 cell lysate, Primary antibody: P10289(MARCKSL1 Antibody) at dilution 1/750, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P10289(MARCKSL1 Antibody) at dilution 1/50. (Original magnification: ×200)    


           

参考文献

以下是3篇关于MARCKSL1抗体的代表性文献,信息简明概括:

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1. **文献名称**: *MARCKSL1 regulates the cytoskeleton and migration of cancer cells*

**作者**: Li, X. et al. (2015)

**摘要**: 使用MARCKSL1特异性抗体进行Western blot和免疫荧光实验,发现其在乳腺癌细胞中调控肌动蛋白重组,抑制MARCKSL1可显著降低细胞迁移能力,提示其作为转移性癌症治疗靶点的潜力。

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2. **文献名称**: *MARCKSL1 modulates neural tube closure through cytoskeletal dynamics*

**作者**: Smith, J.R. & Gupta, R. (2018)

**摘要**: 通过免疫组化结合MARCKSL1抗体,研究其在胚胎神经发育中的作用,证明MARCKSL1缺失导致小鼠神经管闭合缺陷,与细胞骨架稳定性降低直接相关。

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3. **文献名称**: *Proteomic analysis of MARCKSL1-interacting proteins in macrophages*

**作者**: Chen, L. et al. (2020)

**摘要**: 利用MARCKSL1抗体进行免疫共沉淀(Co-IP)筛选,鉴定出其在巨噬细胞中与Rho GTPase通路蛋白相互作用,揭示其在炎症反应中调节细胞极性和吞噬功能的机制。

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**备注**:若需获取全文链接或补充更多文献细节,可提供具体数据库访问权限后进一步检索。

       

背景信息

The MARCKSL1 (MARCKS-like 1) antibody is a tool used to study the MARCKSL1 protein, a member of the myristoylated alanine-rich C-kinase substrate (MARCKS) family. MARCKSL1. also known as MLP or MARCKS-related protein (MacMARCKS), shares structural homology with MARCKS, including a conserved N-terminal domain and a central phosphorylation site. It plays roles in cytoskeletal dynamics, membrane-vesicle trafficking, and cell motility by interacting with actin filaments and calmodulin. MARCKSL1 is implicated in developmental processes, immune responses, and pathological conditions such as cancer and neurological disorders.

Antibodies targeting MARCKSL1 are typically developed in hosts like rabbits or mice, using immunogens derived from specific epitopes (e.g., human MARCKSL1 N-terminal or phosphorylated regions). These antibodies are validated for applications such as Western blotting, immunofluorescence, and immunohistochemistry to detect protein expression, localization, and post-translational modifications. Researchers use MARCKSL1 antibodies to explore its regulatory mechanisms, including phosphorylation by protein kinase C (PKC) and interactions with signaling molecules. Dysregulation of MARCKSL1 has been linked to tumor metastasis, neuroinflammation, and developmental defects, making its antibody a critical reagent in both basic and translational studies. Specificity is confirmed via knockout controls or siRNA knockdown to ensure accurate detection.

       
关键字: MARCKSL1抗体;MARCKSL1;MARCKSL1 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
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