The COMMD9 antibody is a research tool used to detect COMMD9. a member of the conserved oligomeric metalloregulatory (COMMD) protein family. COMMD proteins, including COMMD9. are implicated in diverse cellular processes such as copper homeostasis, NF-κB signaling, and transcriptional regulation. COMMD9 specifically interacts with other COMMD family members and has been linked to cancer progression, particularly in hepatocellular carcinoma and breast cancer, where its dysregulation may influence tumor growth and metastasis.
As a reagent, the COMMD9 antibody is typically developed in hosts like rabbits or mice, targeting specific epitopes of the human COMMD9 protein. It is widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study COMMD9 expression, localization, and function in cell lines or tissues. Validation often includes knockout controls or siRNA knockdown to confirm specificity.
Commercial COMMD9 antibodies are available from multiple suppliers, with applications spanning basic research in metal metabolism, oncology, and inflammation. Recent studies highlight its role in DNA repair pathways and immune responses, underscoring its potential as a biomarker or therapeutic target. Researchers should verify antibody performance in their experimental systems due to variability in cross-reactivity across species or isoforms.