The RPL10A antibody is a research tool designed to detect ribosomal protein L10A (RPL10A), a component of the 60S ribosomal subunit involved in protein synthesis. RPL10A, encoded by the *RPL10A* gene, plays a critical role in ribosome assembly and translation fidelity. It is highly conserved across eukaryotes, reflecting its essential function in cellular homeostasis. Dysregulation of RPL10A has been linked to various pathologies, including cancer and neurodevelopmental disorders. For instance, mutations in *RPL10A* are associated with autism spectrum disorders and T-cell acute lymphoblastic leukemia, highlighting its importance in both neurological and oncological contexts.
Antibodies targeting RPL10A enable researchers to investigate its expression, localization, and interactions in different biological systems. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study ribosome biogenesis, cellular stress responses, and disease mechanisms. Commercial RPL10A antibodies are typically raised in rabbits or mice using synthetic peptides or recombinant proteins as immunogens. Validation steps, including knockout controls and cross-reactivity assessments, are crucial to ensure specificity. As ribosomopathies and cancer research advance, RPL10A antibodies remain vital for elucidating the molecular roles of ribosomal proteins in health and disease.