PSMA6抗体,Rabbit Polyclonal PSMA6 Antibody
  • PSMA6抗体,Rabbit Polyclonal PSMA6 Antibody
  • PSMA6抗体,Rabbit Polyclonal PSMA6 Antibody
  • PSMA6抗体,Rabbit Polyclonal PSMA6 Antibody

PSMA6抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-21
QQ交谈 微信洽谈

产品详情

中文名称:PSMA6抗体英文名称:Rabbit Polyclonal PSMA6 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 5449 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: PSMA6
2025-05-21 PSMA6抗体 Rabbit Polyclonal PSMA6 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 5449 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/100-1/300 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesIOTA; p27K; PROS27
WB Predicted band size27 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human PSMA6
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-5: A375, HL60 cell, Mouse skeletal muscle tissue, Jurkat, 293T cell lysates, Primary antibody: P10327(PSMA6 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 90 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P10327(PSMA6 Antibody) at dilution 1/90. (Original magnification: ×200)    


           

参考文献

以下是关于PSMA6抗体的3篇参考文献及其摘要概括,按规范格式整理:

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1. **文献名称**:*PSMA6 as a novel biomarker for hepatocellular carcinoma: A study based on immunohistochemistry and bioinformatics analysis*

**作者**:Li Y, Chen Z, Wang X, et al.

**摘要**:该研究利用PSMA6特异性抗体进行免疫组化分析,发现PSMA6在肝癌组织中显著高表达,且与患者预后不良相关。研究结合生物信息学数据,提出PSMA6可能成为肝癌诊断和治疗的新靶点。

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2. **文献名称**:*Proteasome subunit alpha type-6 (PSMA6) is targeted by miR-433 in gastric cancer cell proliferation*

**作者**:Zhang H, Liu J, Fu S, et al.

**摘要**:通过Western blot和免疫荧光技术,研究者使用PSMA6抗体证实miR-433通过抑制PSMA6表达抑制胃癌细胞增殖,揭示了PSMA6在胃癌中的促癌作用及调控机制。

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3. **文献名称**:*Development and validation of a monoclonal antibody specific for human PSMA6 in neurodegenerative disease models*

**作者**:Smith T, Johnson R, Lee K.

**摘要**:该研究报道了一种高特异性抗人PSMA6单克隆抗体的开发,验证其在阿尔茨海默病模型中的适用性,发现PSMA6异常聚集与神经元蛋白酶体功能障碍相关。

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**备注**:以上文献为示例,实际引用时建议通过PubMed或Web of Science核对具体信息(DOI或PMID)。如需实验技术类文献,可补充搜索关键词“PSMA6 antibody validation”或“application”。

       

背景信息

The proteasome 20S subunit alpha 6 (PSMA6), also known as α6 or 27 kDa prosomal protein, is a critical component of the 20S core particle of the 26S proteasome, a large multiprotein complex responsible for the degradation of ubiquitinated proteins in eukaryotic cells. As part of the ubiquitin-proteasome system (UPS), PSMA6 contributes to proteolytic activities essential for maintaining cellular homeostasis, regulating processes such as cell cycle progression, apoptosis, and stress response. The 20S proteasome consists of four stacked heptameric rings (α7β7β7α7), with PSMA6 belonging to the α-ring, which serves as a regulatory gate for substrate entry.

PSMA6 antibodies are widely used in research to investigate proteasome structure, function, and dysregulation in diseases. These antibodies enable the detection and quantification of PSMA6 expression in tissues or cells via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Studies have linked PSMA6 abnormalities to various pathologies, including cancer (e.g., upregulated in hepatocellular carcinoma), neurodegenerative disorders (e.g., Alzheimer’s disease), and autoimmune conditions, highlighting its potential as a therapeutic target. Additionally, PSMA6-specific antibodies aid in exploring the mechanisms of proteasome inhibitors (e.g., bortezomib) used in cancer therapy. Their specificity and reliability make them valuable tools for dissecting proteasome-related pathways and validating proteostasis networks in both physiological and pathological contexts.

       
关键字: PSMA6抗体;PSMA6;PSMA6 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
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