RITA1抗体,Rabbit Polyclonal RITA1 Antibody
  • RITA1抗体,Rabbit Polyclonal RITA1 Antibody
  • RITA1抗体,Rabbit Polyclonal RITA1 Antibody
  • RITA1抗体,Rabbit Polyclonal RITA1 Antibody

RITA1抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-21
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产品详情

中文名称:RITA1抗体英文名称:Rabbit Polyclonal RITA1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 5469 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: RITA1
2025-05-21 RITA1抗体 Rabbit Polyclonal RITA1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 5469 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesRITA; C12orf52
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human RITA1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P10354(RITA1 Antibody) at dilution 1/60. (Original magnification: ×200)    


           

参考文献

以下是关于RITA1抗体的3篇参考文献示例(注:以下内容为虚构,仅作示例,实际文献需通过数据库检索确认):

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1. **文献名称**:*RITA1 modulates Notch signaling by interacting with RBP-J and regulating transcriptional activity*

**作者**:Tanaka, N. et al.

**摘要**:本研究通过免疫共沉淀(Co-IP)和染色质免疫沉淀(ChIP)实验,利用特异性RITA1抗体揭示了RITA1蛋白与RBP-J的相互作用机制,证明其在Notch信号通路中负向调控靶基因表达,影响细胞分化。

2. **文献名称**:*Development and validation of a monoclonal antibody for RITA1 in human cancer tissues*

**作者**:Smith, L. et al.

**摘要**:作者开发了一种高特异性RITA1单克隆抗体,并通过Western blot、免疫组化(IHC)和免疫荧光(IF)验证其在乳腺癌和肺癌组织中的表达,发现RITA1低表达与患者预后不良相关。

3. **文献名称**:*Subcellular localization and tubulin association of RITA1 revealed by antibody-based imaging*

**作者**:Garcia-Moreno, J. et al.

**摘要**:使用RITA1抗体进行共聚焦显微镜分析,发现RITA1定位于细胞质并与微管蛋白共定位,提示其在细胞骨架调控和有丝分裂中的潜在作用。

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如需真实文献,建议通过PubMed或Google Scholar搜索关键词“RITA1 antibody”或“RBP-J interacting and tubulin-associated 1”获取最新研究。

       

背景信息

RITA1 (RBP-J interacting and tubulin-associated 1), also known as C12orf52. is a protein encoded by the human gene *C12orf52*. It was initially identified as a binding partner of RBP-J (recombination signal-binding protein for immunoglobulin kappa J region), a key transcription factor in the Notch signaling pathway. RITA1 is implicated in regulating Notch signaling by modulating the interaction between RBP-J and its co-activators or co-repressors, thereby influencing transcriptional activity. Beyond its role in Notch signaling, RITA1 associates with microtubules and is involved in mitotic spindle organization, suggesting a dual function in transcriptional regulation and cell cycle progression.

Antibodies targeting RITA1 have been developed to explore its cellular localization, protein-protein interactions, and mechanistic roles in both physiological and pathological contexts. These antibodies are critical tools for studies using techniques like Western blotting, immunofluorescence, and co-immunoprecipitation. Research has linked RITA1 to cancer biology, particularly in tumors where Notch signaling is dysregulated, such as T-cell acute lymphoblastic leukemia (T-ALL) and breast cancer. Its involvement in mitosis also positions it as a potential biomarker or therapeutic target in malignancies with chromosomal instability. The development and validation of RITA1 antibodies continue to support investigations into its multifaceted roles in cellular processes and disease mechanisms.

       
关键字: RITA1抗体;RITA1;RITA1 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
询盘

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