NMNAT2抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Rat lung tissue lysate, Primary antibody: P10361(NMNAT2 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    

  
  

NMNAT2 (Nicotinamide Nucleotide Adenylyltransferase 2) is a member of the NMNAT enzyme family, which catalyzes the synthesis of nicotinamide adenine dinucleotide (NAD+), a critical coenzyme involved in cellular energy metabolism, DNA repair, and signaling pathways. NMNAT2 is predominantly expressed in the nervous system and plays a vital role in maintaining neuronal health, particularly in axon integrity and protection against neurodegenerative processes. Studies highlight its neuroprotective functions, with reduced NMNAT2 levels linked to axonal degeneration and diseases like Alzheimer’s and Parkinson’s.

NMNAT2 antibodies are essential tools for detecting and quantifying NMNAT2 protein expression in research. They are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study NMNAT2 localization, expression dynamics under stress or disease conditions, and interactions with other proteins. These antibodies help elucidate NMNAT2’s regulatory mechanisms in NAD+ biosynthesis and its involvement in cellular stress responses. Validation of NMNAT2 antibodies often includes knockout controls or siRNA-based silencing to confirm specificity. Due to its emerging role in neuroprotection and aging, NMNAT2 remains a focus in therapeutic research, making its antibodies crucial for advancing understanding of neurodegenerative diseases and potential interventions.