The VTA1 antibody is a research tool used to study the vacuolar protein sorting-associated protein VTA1. a critical component of the Endosomal Sorting Complex Required for Transport (ESCRT) pathway. VTA1 plays a key role in membrane remodeling processes, including cytokinesis, viral budding, and multivesicular body formation. It functions as a cofactor for VPS4 ATPase, facilitating the disassembly and recycling of ESCRT-III subunits during membrane scission. VTA1 interacts with other ESCRT-associated proteins, such as VPS60 or SBP1. forming distinct complexes (e.g., ESCORT-III) that regulate membrane deformation and cargo sorting.
Antibodies targeting VTA1 enable the investigation of its expression, localization, and molecular interactions in cellular models. They are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to explore VTA1's role in physiological and pathological contexts. Dysregulation of VTA1 has been implicated in cancer progression, neurodegenerative diseases, and viral infections (e.g., HIV), as ESCRT dysfunction can disrupt membrane integrity, signaling, and intracellular trafficking. Researchers also utilize VTA1 antibodies to study its involvement in autophagy, lysosomal degradation, and cellular stress responses. These tools contribute to understanding how VTA1-mediated membrane dynamics influence disease mechanisms and potential therapeutic targets.