The FKBP3 antibody is a tool used to detect FK506-binding protein 3 (FKBP3), also known as FKBP25. a member of the immunophilin protein family. FKBP3 belongs to the FKBP subfamily, characterized by peptidyl-prolyl cis-trans isomerase (PPIase) activity, which assists in protein folding and modulates signaling pathways. This 25 kDa protein contains a nuclear localization signal and is primarily found in the nucleus, where it interacts with chromatin-remodeling complexes, histones, and transcription factors. Its role in regulating enzymatic activity or signaling cascades remains partially understood, but it has been implicated in cellular stress responses, apoptosis, and epigenetic regulation.
FKBP3 antibodies are widely employed in research to study protein localization, expression levels, and interactions via techniques like Western blotting, immunoprecipitation, and immunofluorescence. Dysregulation of FKBP3 has been observed in cancer, neurodegenerative diseases, and immune disorders, making it a potential biomarker or therapeutic target. For instance, FKBP3 overexpression in certain cancers correlates with chemoresistance, while its interaction with tau protein in Alzheimer’s models suggests involvement in neuropathology.
These antibodies are critical for elucidating FKBP3’s molecular mechanisms and validating its involvement in disease pathways, aiding drug discovery and functional genomics studies.