HSPA13抗体,Rabbit Polyclonal HSPA13 Antibody
  • HSPA13抗体,Rabbit Polyclonal HSPA13 Antibody
  • HSPA13抗体,Rabbit Polyclonal HSPA13 Antibody
  • HSPA13抗体,Rabbit Polyclonal HSPA13 Antibody

HSPA13抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-21
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产品详情

中文名称:HSPA13抗体英文名称:Rabbit Polyclonal HSPA13 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 5606 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: HSPA13
2025-05-21 HSPA13抗体 Rabbit Polyclonal HSPA13 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 5606 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/100-1/300 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesSTCH
WB Predicted band size52 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human HSPA13
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human uterus tissue lysate, Primary antibody: P10541(HSPA13 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 3 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P10541(HSPA13 Antibody) at dilution 1/90. (Original magnification: ×200)    


           

参考文献

以下是关于HSPA13抗体的示例参考文献(注:以下内容为示例,实际文献需通过数据库验证):

1. **文献名称**:*HSPA13 regulates cancer cell proliferation via ER stress signaling pathways*

**作者**:Smith J, et al.

**摘要**:本研究利用HSPA13特异性抗体,通过Western blot和免疫荧光技术,揭示了HSPA13在内质网应激反应中的作用,并证明其表达水平与肿瘤细胞增殖能力相关。

2. **文献名称**:*Characterization of a novel monoclonal antibody against HSPA13 and its application in neurodegenerative disease models*

**作者**:Chen L, et al.

**摘要**:作者开发了一种新型HSPA13单克隆抗体,验证其特异性后,应用于阿尔茨海默病模型,发现HSPA13在神经元内异常聚集,提示其与tau蛋白病理相关。

3. **文献名称**:*HSPA13 expression correlates with poor prognosis in gastric cancer*

**作者**:Wang Y, et al.

**摘要**:通过免疫组化(使用HSPA13抗体)分析胃癌组织样本,发现HSPA13高表达与患者生存期缩短显著相关,提示其作为潜在预后标志物的可能性。

4. **文献名称**:*HSPA13 modulates protein folding stress in the endoplasmic reticulum*

**作者**:Zhang R, et al.

**摘要**:研究利用HSPA13抗体进行敲低和过表达实验,发现HSPA13通过调控未折叠蛋白反应(UPR)通路,影响细胞对内质网应激的耐受能力。

建议通过PubMed或Google Scholar以关键词“HSPA13 antibody”、“HSPA13 function”等检索最新文献获取具体信息。

       

背景信息

The HSPA13 antibody targets the heat shock protein family A (HSP70) member 13. a chaperone protein involved in cellular stress responses and protein homeostasis. HSPA13. also known as STCH or HSP70B′, is a member of the HSP70 family localized primarily in the endoplasmic reticulum (ER). Unlike other HSP70s, HSPA13 lacks an ATPase domain but retains substrate-binding capabilities, enabling participation in protein folding, degradation, and translocation. It plays roles in ER-associated degradation (ERAD), apoptosis regulation, and cellular adaptation to stressors like hypoxia or nutrient deprivation. Dysregulation of HSPA13 has been linked to cancer progression, neurodegenerative diseases, and immune disorders, highlighting its potential as a therapeutic target.

HSPA13 antibodies are critical tools for studying its expression, localization, and function. They are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess protein levels in disease models or physiological conditions. These antibodies help elucidate HSPA13's interaction networks, post-translational modifications, and mechanistic contributions to stress adaptation. Commercial HSPA13 antibodies are typically validated for specificity against conserved epitopes, though cross-reactivity with other HSP70 members requires careful experimental controls. Research utilizing these antibodies continues to expand our understanding of HSPA13's role in cellular resilience and pathology.

       
关键字: HSPA13抗体;HSPA13;HSPA13 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
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