SHCBP1 (SHC SH2 Domain-Binding Protein 1) is a protein encoded by the SHCBP1 gene, which belongs to the SHC (Src Homology 2 Domain-Containing) family. This protein interacts with the SH2 domain of SHC1. a key adaptor molecule in growth factor receptor signaling pathways. SHCBP1 is implicated in regulating cell cycle progression, particularly during mitosis, and plays a role in chromosomal segregation and spindle assembly. Studies highlight its involvement in cellular proliferation, differentiation, and apoptosis, with dysregulation linked to various cancers, including breast, gastric, and colorectal cancers, where its overexpression often correlates with poor prognosis.
SHCBP1 antibodies are essential tools for investigating its biological functions and pathological roles. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect SHCBP1 expression levels, subcellular localization, and interaction partners. Research utilizing SHCBP1 antibodies has revealed its association with tumorigenesis, including promoting cancer cell proliferation, invasion, and metastasis. Additionally, SHCBP1 antibodies help explore its potential as a diagnostic biomarker or therapeutic target. Validation of antibody specificity, often through knockout or knockdown models, ensures reliable detection in both physiological and disease contexts, advancing understanding of SHCBP1's molecular mechanisms in health and cancer.