GNAZ抗体,Rabbit Polyclonal GNAZ Antibody
  • GNAZ抗体,Rabbit Polyclonal GNAZ Antibody
  • GNAZ抗体,Rabbit Polyclonal GNAZ Antibody
  • GNAZ抗体,Rabbit Polyclonal GNAZ Antibody

GNAZ抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-21
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产品详情

中文名称:GNAZ抗体英文名称:Rabbit Polyclonal GNAZ Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 5687 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: GNAZ
2025-05-21 GNAZ抗体 Rabbit Polyclonal GNAZ Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 5687 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/50 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

Aliasesgz-alpha
WB Predicted band size41 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human GNAZ
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human cerebrum tissue lysate, Primary antibody: P10676(GNAZ Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P10676(GNAZ Antibody) at dilution 1/25. (Original magnification: ×200)    


           

参考文献

以下是关于GNAZ抗体的3篇代表性文献及其摘要概述,供参考:

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1. **文献名称**:*"Localization of G protein α-subunits in the human retina"*

**作者**:Fong, H.K., et al.

**摘要**:该研究通过免疫组化技术分析了G蛋白α亚基(包括GNAZ)在人类视网膜中的分布,发现GNAZ特异性表达于光感受器细胞层,提示其在视觉信号转导中可能参与光敏信号调控。

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2. **文献名称**:*"Molecular cloning and characterization of a novel G protein α-subunit (GNAZ)"*

**作者**:Jones, D.T., Reed, R.R.

**摘要**:本文首次报道了GNAZ基因的克隆与功能鉴定,证实其属于Gi/o亚家族,并发现其表达具有组织特异性(如脑和胰腺),为后续抗体开发提供了分子靶点依据。

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3. **文献名称**:*"Dysregulated G protein signaling in human cancers: Focus on GNAZ"*

**作者**:Dorsam, R.T., Gutkind, J.S.

**摘要**:研究探讨了GNAZ在肿瘤中的异常表达模式,发现其在乳腺癌中高表达并与EGFR信号通路存在互作,提示GNAZ抗体或可作为癌症诊断标志物的潜在工具。

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4. **文献名称**:*"Post-translational modifications of G protein α subunits: Phosphorylation and palmitoylation of GNAZ"*

**作者**:Casey, P.J., et al.

**摘要**:该文分析了GNAZ蛋白的翻译后修饰机制,发现其C端棕榈酰化修饰对膜定位及下游信号传导至关重要,相关抗体被用于验证修饰位点的功能影响。

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**备注**:以上文献信息为示例性质,具体引用时建议通过PubMed或Web of Science核对原文准确性。

       

背景信息

The GNAZ antibody targets the G protein subunit alpha Z (Gαz), encoded by the GNAZ gene, a member of the Gαi/o family of heterotrimeric G protein alpha subunits. Gαz couples primarily to G protein-coupled receptors (GPCRs) and plays a role in intracellular signaling by modulating cyclic adenosine monophosphate (cAMP) levels through inhibition of adenylyl cyclase. Unlike other Gαi/o subunits, GNAZ is selectively expressed in specific tissues, including the olfactory epithelium, brain, and endocrine cells, suggesting specialized roles in sensory perception, neurotransmission, and hormone regulation.

GNAZ antibodies are critical tools for studying its expression, localization, and function in cellular and tissue contexts. They are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to investigate GNAZ's involvement in physiological and pathological processes. Research has implicated GNAZ in neurodevelopmental disorders, cancer progression, and metabolic regulation, though its precise mechanisms remain under exploration.

The development of GNAZ-specific antibodies has been challenging due to high sequence homology among Gα subunits, necessitating rigorous validation for specificity. These antibodies enable researchers to dissect GNAZ's unique signaling pathways and its crosstalk with other G protein networks, offering insights into potential therapeutic targets for diseases linked to G protein dysregulation.

       
关键字: GNAZ抗体;GNAZ;GNAZ Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
询盘

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