CMTM1 (CKLF-like MARVEL transmembrane domain-containing 1) is a member of the CMTM family, which shares structural similarities with both chemokine-like factor (CKLF) and MARVEL domain-containing proteins. It plays roles in cellular processes such as proliferation, apoptosis, and immune regulation. CMTM1 is expressed in various tissues, including immune cells, the male reproductive system, and certain cancers. Studies suggest its involvement in tumor suppression or progression, depending on context, potentially through modulation of signaling pathways like EGFR or PI3K/AKT.
Antibodies targeting CMTM1 are essential tools for detecting its expression and localization in cells or tissues. These antibodies enable techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study CMTM1's role in physiological and pathological conditions. For example, researchers use them to compare CMTM1 levels in normal versus cancerous tissues or to explore its interaction with immune checkpoints.
Commercial CMTM1 antibodies are available from multiple suppliers (e.g., Sigma-Aldrich, Abcam), often validated for specificity and sensitivity. However, batch variability and cross-reactivity with other CMTM family members require careful validation using knockout controls. Ongoing research aims to clarify CMTM1's dual roles in cancer and its potential as a therapeutic target or biomarker, driving demand for reliable antibodies in both basic and translational studies.