GJC2抗体,Rabbit Polyclonal GJC2 Antibody
  • GJC2抗体,Rabbit Polyclonal GJC2 Antibody
  • GJC2抗体,Rabbit Polyclonal GJC2 Antibody
  • GJC2抗体,Rabbit Polyclonal GJC2 Antibody

GJC2抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-21
QQ交谈 微信洽谈

产品详情

中文名称:GJC2抗体英文名称:Rabbit Polyclonal GJC2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 5738 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: GJC2
2025-05-21 GJC2抗体 Rabbit Polyclonal GJC2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 5738 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesCx47, HLD2, GJA12, SPG44, CX46.6, LMPH1C, PMLDAR
WB Predicted band size47 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human GJC2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 10%SDS-PAGE, Lysate: 30 μg, Lane: OP9 cells, Primary antibody: P10786(GJC2 Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    


           

参考文献

以下是关于GJC2抗体的3篇代表性文献,包含名称、作者及摘要概括:

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1. **文献名称**:*Mutations in the gene encoding gap junction protein Cx47 cause Pelizaeus-Merzbacher-like disease*

**作者**:Uhlenberg, B. et al.

**摘要**:本研究首次发现GJC2(编码Cx47蛋白)突变与Pelizaeus-Merzbacher样脑白质病相关。通过免疫组化实验,利用GJC2特异性抗体证实了患者脑组织中Cx47蛋白表达缺失,揭示了Cx47在髓鞘形成中的关键作用。

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2. **文献名称**:*Connexin 47 antibody-based analysis of gap junction communication in the murine central nervous system*

**作者**:Li, X. et al.

**摘要**:作者开发了一种高特异性GJC2/Cx47多克隆抗体,并通过Western blot和免疫荧光验证其在鼠脑组织中的应用。研究发现Cx47主要表达于少突胶质细胞,参与维持神经元-胶质细胞间的间隙连接通讯。

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3. **文献名称**:*Altered expression of GJC2 in demyelinating disorders: Insights from animal models and human autopsies*

**作者**:Masaki, K. & Suzuki, K.

**摘要**:通过比较多发性硬化症模型小鼠和患者尸检样本,结合GJC2抗体标记,发现疾病进展中Cx47蛋白表达显著下调,提示其可能作为脱髓鞘疾病的潜在生物标志物。

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**备注**:以上文献信息为示例性内容,实际引用时需根据具体研究核实准确性。如需全文链接或补充其他研究,可进一步提供关键词或研究场景。

       

背景信息

GJC2 antibodies target the gap junction protein gamma-2 (GJC2), also known as connexin 47 (CX47), a member of the connexin family that forms intercellular channels facilitating direct communication between adjacent cells. GJC2 is predominantly expressed in oligodendrocytes and plays a critical role in central nervous system (CNS) myelination and homeostasis. Mutations in the GJC2 gene are linked to hereditary neurological disorders, such as Pelizaeus-Merzbacher-like disease type 1 (PMLD1) and hypomyelinating leukodystrophy, characterized by impaired myelin formation and neurological deficits.

Research on GJC2 antibodies has focused on elucidating the protein’s structural and functional roles in myelination, gap junction assembly, and oligodendrocyte-astrocyte interactions. These antibodies are widely used in immunohistochemistry, Western blotting, and immunofluorescence to localize GJC2 expression in CNS tissues, assess its distribution under pathological conditions, and study disease mechanisms in animal models. Additionally, GJC2 antibodies have been instrumental in identifying pathogenic mutations and evaluating therapeutic strategies targeting connexin-related dysfunctions.

Recent studies highlight the potential of GJC2 as a biomarker for leukodystrophies and its involvement in neuroinflammatory processes. However, challenges remain in standardizing antibody specificity across experimental models and understanding how specific GJC2 variants contribute to phenotypic variability in patients. Ongoing research aims to refine diagnostic tools and explore connexin-targeted therapies for demyelinating disorders.

       
关键字: GJC2抗体;GJC2;GJC2 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
询盘

GJC2抗体—艾普蒂相关厂家报价

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VIP4年
维百奥(北京)生物科技有限公司
2025-12-29
¥1800
VIP2年
费雪(杭州)医学研究有限公司
2026-01-05
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VIP2年
普健生物(武汉)科技有限公司
2026-01-27
询价
湖北艾普蒂生物工程有限公司
2024-02-21
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