The CLDND1 (Claudin Domain Containing 1) antibody is a tool used to detect the CLDND1 protein, a member of the claudin-like protein family. Although CLDND1 shares structural homology with claudins—key components of tight junctions that regulate paracellular transport and cell polarity—it lacks canonical claudin motifs and exhibits distinct functional roles. CLDND1 is implicated in embryonic development, particularly in neurogenesis and epithelial barrier formation, though its precise mechanisms remain under investigation. Studies suggest its involvement in cell adhesion, membrane organization, and signaling pathways, such as Notch signaling. Dysregulation of CLDND1 has been linked to developmental disorders, including kidney defects and neurological abnormalities. In cancer, altered CLDND1 expression is observed in certain tumors, potentially influencing metastasis or cell proliferation. The CLDND1 antibody is widely used in research applications like immunohistochemistry, Western blotting, and immunofluorescence to study protein localization, expression levels, and interactions in both normal and diseased tissues. Commercial antibodies are typically raised against specific epitopes, often validated for reactivity in human or murine models. Ongoing research aims to clarify CLDND1's biological significance and its potential as a therapeutic or diagnostic target.