The HOXA4 antibody is a crucial tool for studying the HOXA4 protein, encoded by the HOXA4 gene within the Homeobox (HOX) gene family. HOX genes, highly conserved across species, regulate embryonic development, particularly axial patterning and organogenesis. HOXA4. located in the HOXA cluster on chromosome 7. plays roles in defining segmental identity along the anterior-posterior axis, influencing the development of the hindbrain, spinal cord, and organs like the lungs and gastrointestinal tract. Dysregulation of HOXA4 has been implicated in developmental disorders and cancers, including colorectal and esophageal malignancies.
HOXA4 antibodies enable detection and localization of the HOXA4 protein in tissues or cells via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies are essential for investigating HOXA4's expression patterns, interactions, and regulatory mechanisms. Researchers utilize them to explore HOXA4's role in stem cell differentiation, tissue regeneration, and disease progression. Specificity and validation (e.g., knockout controls) are critical when selecting HOXA4 antibodies, as cross-reactivity with other HOX proteins may occur. Both monoclonal and polyclonal variants are available, each offering distinct advantages in sensitivity and application flexibility. Overall, HOXA4 antibodies are vital for advancing studies in developmental biology, oncology, and regenerative medicine.