The KCNC4 antibody targets the potassium voltage-gated channel subfamily C member 4 (KCNC4), a protein encoded by the *KCNC4* gene. KCNC4. also known as Kv3.4. belongs to the Kv3 family of voltage-gated potassium channels, which regulate high-frequency neuronal firing and action potential repolarization. This channel is prominently expressed in the nervous system, particularly in sensory neurons, and plays roles in synaptic transmission, excitability, and neuroprotection.
KCNC4 antibodies are essential tools for studying the channel's expression, localization, and function. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect KCNC4 in tissues or cultured cells. These antibodies aid in exploring KCNC4's involvement in neurological disorders, such as epilepsy, ataxia, and neurodegenerative diseases, where altered potassium channel activity is implicated.
Developing KCNC4 antibodies requires careful validation due to structural similarities among Kv3 family members, which can lead to cross-reactivity. High-specificity antibodies help dissect KCNC4's unique physiological roles, such as its interaction with modulatory proteins or response to oxidative stress. Recent studies also link KCNC4 dysfunction to pathologies like myotonia and pain hypersensitivity, highlighting its therapeutic potential. Overall, KCNC4 antibodies are critical for advancing research into neuronal excitability and channelopathy-related diseases.