**Background of BPIFB3 Antibody**
BPIFB3 (BPI Fold Containing Family B Member 3) is a member of the bactericidal/permeability-increasing protein (BPI) family, characterized by conserved structural motifs involved in lipid binding and innate immunity. Located on chromosome 20. BPIFB3 is primarily expressed in mucosal tissues, including the respiratory and gastrointestinal tracts, and is implicated in inflammatory responses and lipid metabolism. It shares structural homology with other BPI family proteins, featuring a characteristic N-terminal BPI domain that may mediate antimicrobial or immunomodulatory functions.
BPIFB3 has garnered interest due to its potential role in chronic inflammatory diseases and cancer. Studies suggest it may regulate cell proliferation, apoptosis, and immune signaling, with altered expression observed in conditions like chronic rhinosinusitis, inflammatory bowel disease, and certain carcinomas. Its exact biological mechanisms remain under investigation, though interactions with Toll-like receptors (TLRs) and involvement in lipid-associated pathways have been proposed.
Antibodies targeting BPIFB3 are essential tools for elucidating its function and localization. They enable detection of protein expression in tissues or cell lines via techniques like Western blot, immunohistochemistry, or immunofluorescence. Such reagents also aid in exploring BPIFB3's diagnostic or therapeutic potential, particularly in diseases linked to dysregulated mucosal immunity. Ongoing research aims to clarify its dual roles in host defense and pathology, positioning BPIFB3 as a molecule of growing relevance in immunology and oncology.