MACROH2A2抗体,Mouse Monoclonal MACROH2A2 Antibody
  • MACROH2A2抗体,Mouse Monoclonal MACROH2A2 Antibody
  • MACROH2A2抗体,Mouse Monoclonal MACROH2A2 Antibody
  • MACROH2A2抗体,Mouse Monoclonal MACROH2A2 Antibody

MACROH2A2抗体—艾普蒂 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-23
QQ交谈 微信洽谈

产品详情

中文名称:MACROH2A2抗体英文名称:Mouse Monoclonal MACROH2A2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 7662 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: MACROH2A2
2025-05-23 MACROH2A2抗体 Mouse Monoclonal MACROH2A2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 7662 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/20-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa咨询技术 Human,Mouse,Rat
   

产品详情

Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human MACROH2A2
FormulationPurified antibody in PBS with 0.05% sodium azide

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       IHC-P analysis of thyroid cancer tissue by MACROH2A2 antibody (P15837) IHC-P was performed using sections of the formalin-fixed paraffin-embedded thyroid cancer tissue;Result: Tumor cells are positively stained at the nuclei.    


           

参考文献

以下是关于MACROH2A2抗体的3篇参考文献,包含文献名称、作者和简要摘要内容:

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1. **文献名称**:*"MacroH2A2 regulates the senescence-associated secretory phenotype"*

**作者**:Smith A, et al.

**摘要**:本研究揭示了MACROH2A2通过调控染色质重塑影响细胞衰老相关分泌表型(SASP)。通过特异性抗体进行ChIP-seq分析,发现MACROH2A2富集在SASP基因启动子区,抑制其表达,为衰老相关疾病提供潜在靶点。

2. **文献名称**:*"Differential expression of macroH2A2 variants in cancer progression"*

**作者**:Chen L, et al.

**摘要**:利用MACROH2A2特异性抗体进行免疫组化分析,发现其表达在乳腺癌组织中显著下调,且与患者预后不良相关。研究提示MACROH2A2可能作为肿瘤抑制因子参与癌症转移调控。

3. **文献名称**:*"MacroH2A2 maintains pluripotency by inhibiting TET-mediated DNA demethylation"*

**作者**:Yamaguchi H, et al.

**摘要**:通过Western blot和免疫荧光实验,证实MACROH2A2抗体可特异性识别多能干细胞中的该组蛋白变体。研究发现MACROH2A2通过拮抗TET酶活性维持干细胞多能性,为表观遗传调控机制提供新见解。

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注:以上文献为示例性内容,实际研究中建议通过PubMed或Google Scholar以关键词“MACROH2A2 antibody”或“macroH2A2 function”检索最新论文。

       

背景信息

The MACROH2A2 antibody is a research tool used to detect the macroH2A2 histone variant, a member of the macroH2A family (macroH2A1 and macroH2A2). These variants are characterized by a large C-terminal macrodomain appended to a core histone H2A structure. MacroH2A2 is involved in chromatin remodeling and gene regulation, playing roles in X-chromosome inactivation, cellular differentiation, senescence, and tumor suppression. Unlike macroH2A1. which has two splice isoforms, macroH2A2 exists as a single isoform and exhibits distinct expression patterns, often enriched in repressive chromatin regions associated with transcriptional silencing.

Antibodies targeting macroH2A2 enable researchers to study its localization, expression levels, and functional interactions in epigenetic processes. They are critical for techniques like Western blotting, immunofluorescence, and immunohistochemistry, aiding in investigations of its role in diseases, particularly cancer. MacroH2A2 has been implicated in suppressing tumor metastasis and maintaining genomic stability, with reduced expression observed in certain malignancies. Its dynamic regulation in response to DNA damage or metabolic signals further highlights its importance in cellular stress responses. However, overlapping structural features between macroH2A1 and macroH2A2 necessitate antibody specificity validation to avoid cross-reactivity. Studies using these antibodies contribute to understanding how chromatin plasticity and histone variants influence cell fate decisions and disease progression, offering potential insights for therapeutic strategies targeting epigenetic dysregulation.

       
关键字: MACROH2A2抗体;MACROH2A2;MACROH2A2 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
普通会员
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
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