BABAM1抗体,Mouse Monoclonal BABAM1 Antibody
  • BABAM1抗体,Mouse Monoclonal BABAM1 Antibody
  • BABAM1抗体,Mouse Monoclonal BABAM1 Antibody
  • BABAM1抗体,Mouse Monoclonal BABAM1 Antibody

BABAM1抗体—艾普蒂 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-23
QQ交谈 微信洽谈

产品详情

中文名称:BABAM1抗体英文名称:Mouse Monoclonal BABAM1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 7674 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: BABAM1
2025-05-23 BABAM1抗体 Mouse Monoclonal BABAM1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 7674 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/250 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa咨询技术 Human,Mouse,Rat
   

产品详情

Host/IsotypeMouse IgG2a
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human BABAM1
FormulationPurified antibody in PBS with 0.05% sodium azide

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       IHC-P analysis of testis tissue by BABAM1 antibody (P15869) IHC-P was performed using sections of the formalin-fixed paraffin-embedded testis tissue;Result: Cells in seminiferous ducts are positively stained at the nuclei and cytoplasm.    


           

参考文献

以下是关于BABAM1抗体的3篇参考文献及其摘要概括:

1. **文献名称**:*BABAM1 regulates the stability and function of the BRCA1-BRCA2-PALB2 complex in DNA repair*

**作者**:Hu Y. et al.

**摘要**:该研究利用BABAM1特异性抗体,通过免疫共沉淀和蛋白质印迹技术,揭示了BABAM1在维持BRCA1复合体稳定性中的作用,并证明其缺失导致DNA同源重组修复缺陷,增加细胞对放疗的敏感性。

2. **文献名称**:*BABAM1 interacts with the BRISC deubiquitinase complex to regulate inflammatory signaling*

**作者**:Sato Y. et al.

**摘要**:研究通过免疫荧光和Western blot技术,结合BABAM1抗体,发现BABAM1与去泛素化酶复合体BRISC相互作用,调控炎症相关信号通路(如NF-κB),为自身免疫疾病治疗提供潜在靶点。

3. **文献名称**:*The role of BABAM1 in breast cancer progression and its clinical implications*

**作者**:Wang L. et al.

**摘要**:通过免疫组织化学(IHC)分析乳腺癌组织样本,发现BABAM1表达水平与患者预后显著相关,低表达患者总生存期较短,提示BABAM1可能作为乳腺癌的生物标志物。

这些文献展示了BABAM1抗体在机制研究(DNA修复、炎症调控)及临床转化(癌症预后评估)中的关键应用。

       

背景信息

**Background of BABAM1 Antibody**

BABAM1 (BRISC and BRCA1-A complex member 1), also known as CCDC98 or BRE, is a multifunctional protein implicated in DNA damage response, cell cycle regulation, and immune signaling. It serves as a critical component of two distinct complexes: the BRCA1-A complex, which facilitates DNA repair through homologous recombination by deubiquitinating γ-H2AX, and the BRISC complex, which regulates inflammatory signaling by modulating type I interferon and NF-κB pathways.

BABAM1 antibodies are valuable tools for studying its role in maintaining genomic stability and its association with diseases. Research highlights BABAM1's interaction with BRCA1. linking it to breast and ovarian cancers, particularly in individuals with BRCA1 mutations. Additionally, BRISC-associated BABAM1 has been implicated in autoimmune disorders and chronic inflammation, emphasizing its dual context-dependent functions.

Antibodies targeting BABAM1 are used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to analyze expression levels, subcellular localization, and protein-protein interactions. Studies utilizing these antibodies have revealed BABAM1's modular structure, including tandem BRCA1-binding domains and coiled-coil regions essential for complex assembly.

Overall, BABAM1 antibodies advance understanding of its contributions to cancer biology, immune regulation, and potential therapeutic targeting, making them crucial for both basic research and clinical applications.

       
关键字: BABAM1抗体;BABAM1;BABAM1 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
询盘

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