RNF150抗体—艾普蒂 新品

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     IHC-P analysis of endometrium tissue by RNF150 antibody (P15990) IHC-P was performed using sections of the formalin-fixed paraffin-embedded endometrium tissue;Result: Glandular cells are positively stained at the cytoplasm and cell membrane.    

  
  

The RNF150 antibody is a research tool designed to target the Ring Finger Protein 150 (RNF150), a member of the E3 ubiquitin ligase family characterized by a conserved RING (Really Interesting New Gene) domain. RNF150 plays a role in ubiquitination, a post-translational modification process that regulates protein degradation, localization, and interactions. Primarily expressed in the nervous system, RNF150 is implicated in modulating neuronal excitability and synaptic function by interacting with ion channels and receptors, such as voltage-gated sodium channels. Its activity influences cellular processes like membrane trafficking and signal transduction, with potential links to neurological disorders, including epilepsy and neuropathic pain.

Research using RNF150 antibodies focuses on elucidating its expression patterns, substrate specificity, and mechanistic roles in health and disease. These antibodies are commonly employed in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to detect protein levels, assess tissue distribution (e.g., brain, heart, and kidney), and identify binding partners. Studies suggest RNF150 may also contribute to cardiovascular and metabolic regulation, though its full biological scope remains under investigation. Validation of antibody specificity—via knockout controls or peptide-blocking assays—is critical due to potential cross-reactivity with homologous E3 ligases. Overall, RNF150 antibodies are vital for advancing understanding of ubiquitin-dependent pathways and their therapeutic implications.