The ASRGL1 (Asparaginase-like protein 1) antibody is a tool used to detect and study the ASRGL1 protein, a member of the asparaginase family. ASRGL1 encodes an enzyme with dual functions: L-asparaginase activity, which hydrolyzes asparagine to aspartate, and isoaspartyl peptidase activity, involved in repairing damaged aspartyl residues in proteins. This protein is ubiquitously expressed but shows elevated levels in reproductive tissues, including the ovary and uterus, and the central nervous system.
Research highlights ASRGL1's role in cellular homeostasis, protein quality control, and its potential link to diseases. In oncology, ASRGL1 is implicated as a tumor suppressor, with reduced expression observed in ovarian, endometrial, and breast cancers, correlating with poor prognosis. Conversely, in neurodegenerative disorders like Alzheimer’s disease, ASRGL1 may contribute to clearing misfolded proteins.
The ASRGL1 antibody is crucial for techniques like immunohistochemistry, Western blotting, and immunofluorescence to analyze protein expression, localization, and pathological relevance. Its development aids in exploring ASRGL1’s diagnostic or prognostic utility in cancer and neurodegeneration, though clinical applications remain under investigation. Ongoing studies focus on mechanistic insights and therapeutic targeting, emphasizing its dual enzymatic roles in disease pathways.