IRAG2抗体,Mouse Monoclonal IRAG2 Antibody
  • IRAG2抗体,Mouse Monoclonal IRAG2 Antibody
  • IRAG2抗体,Mouse Monoclonal IRAG2 Antibody
  • IRAG2抗体,Mouse Monoclonal IRAG2 Antibody

IRAG2抗体—艾普蒂 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-23
QQ交谈 微信洽谈

产品详情

中文名称:IRAG2抗体英文名称:Mouse Monoclonal IRAG2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 7758 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: IRAG2
2025-05-23 IRAG2抗体 Mouse Monoclonal IRAG2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 7758 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF1/100-1/200 Human,Mouse,Rat
IHC1/20-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa咨询技术 Human,Mouse,Rat
   

产品详情

Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human IRAG2
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Western blot analysis using IRAG2 mouse mAb against  Ramos lysate    


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       Lane 1: Ramos lysate ;  Lane 2: IRAG2 immunoprecipitated from Ramos lysate by P16366 ;  Lane 3: The same as Lane 2 but use IgG isotype control antibody ;Result: P16366 can immunoprecipitate IRAG2;    


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       IHC-P analysis of tonsil tissue by IRAG2 antibody (P16366) IHC-P was performed using sections of the formalin-fixed paraffin-embedded tonsil tissue;Result: Germinal center cells and non-germinal center cells are positively stained at the cytoplasm and membrane.    


           

参考文献

以下是关于IRAG2抗体的假设性参考文献示例(仅供格式参考,建议通过学术数据库获取最新文献):

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1. **文献名称**: *IRAG2 modulates cGMP-dependent signaling in vascular smooth muscle cells*

**作者**: Schmidt H, et al.

**摘要**: 研究揭示了IRAG2蛋白通过结合IP3受体和cGMP依赖性激酶调控血管平滑肌细胞钙离子稳态,开发的IRAG2特异性抗体被用于验证其与信号复合物的相互作用。

2. **文献名称**: *Development of a monoclonal antibody for IRAG2 and its application in cardiac hypertrophy models*

**作者**: Nakamura K, et al.

**摘要**: 报道了一种高特异性IRAG2单克隆抗体的制备,并通过免疫组化证实IRAG2在心肌肥大模型中的表达上调,提示其在心脏疾病中的潜在作用。

3. **文献名称**: *IRAG2-antibody based detection of protein-protein interactions in platelet activation*

**作者**: Zhang M, et al.

**摘要**: 利用IRAG2抗体探究其与G蛋白偶联受体的结合机制,发现IRAG2在血小板活化过程中通过调控钙信号影响血栓形成。

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**注意**:以上文献为示例,IRAG2相关研究可能较少,建议通过**PubMed**或**Google Scholar**以关键词“IRAG2 antibody”、“IP3R-associated protein”等检索最新成果。

       

背景信息

The IRAG2 (Inositol 1.4.5-Triphosphate Receptor-Associated GTPase 2) protein, also known as MRVI1 (Murine Retrovirus Integration Site 1 Homolog), is a GTPase implicated in cellular signaling pathways. It interacts with the inositol 1.4.5-triphosphate receptor (IP3R), a key regulator of calcium release from the endoplasmic reticulum, suggesting its role in modulating calcium homeostasis. IRAG2 is encoded by the MRVI1 gene and is structurally related to IRAG1. another IP3R-associated protein involved in nitric oxide/cGMP-dependent signaling. While IRAG1 is well-characterized in vascular smooth muscle contraction, IRAG2's precise functional mechanisms remain less understood, though it is hypothesized to influence phosphoinositide signaling and intracellular calcium dynamics.

Antibodies targeting IRAG2 are primarily used as research tools to investigate its expression, localization, and interaction partners. Studies suggest IRAG2 may contribute to pathological conditions, including cancer progression and cardiovascular diseases, due to its regulatory effects on cell proliferation and apoptosis. Commercial IRAG2 antibodies are typically validated for applications like Western blotting, immunohistochemistry, and immunofluorescence, aiding in elucidating its tissue-specific roles. Recent research also explores its potential as a biomarker or therapeutic target, though further validation is needed. The development of specific, high-affinity IRAG2 antibodies remains critical for advancing understanding of its physiological and pathological relevance.

       
关键字: IRAG2抗体;IRAG2;IRAG2 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
普通会员
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
询盘

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