Pygopus2抗体—艾普蒂 新品

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     Western blot analysis of Pygopus 2 in (1) HeLa cell lysate; (2) MCF-7 cell lysate.    

  
  

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     Immunohistochemical analysis of paraffin-embedded human uterus, using Pygopus 2 Antibody.    

  
  

**Background of Pygopus2 (Pygo2) Antibody**

Pygopus2 (Pygo2) is a nuclear protein that functions as a key coactivator in the Wnt/β-catenin signaling pathway, playing a critical role in embryonic development, tissue homeostasis, and stem cell maintenance. It is a member of the Pygopus family, characterized by a conserved N-terminal plant homeodomain (PHD) involved in chromatin interaction and a C-terminal C-clamp domain that mediates binding to specific DNA-associated factors. Pygo2 facilitates β-catenin-dependent transcriptional activation by bridging β-catenin to chromatin-modifying complexes, such as histone acetyltransferases, thereby enhancing target gene expression.

The Pygo2 antibody is a widely used tool to study its expression, localization, and function in both normal and pathological contexts. It is essential for detecting Pygo2 in techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding in research on developmental biology, cancer (e.g., breast, lung, and colorectal tumors), and stem cell regulation. Dysregulation of Pygo2 has been linked to tumor progression, metastasis, and poor prognosis, highlighting its potential as a therapeutic target. The antibody’s specificity enables researchers to explore Pygo2’s interaction networks, post-translational modifications, and role in chromatin remodeling, contributing to a deeper understanding of Wnt signaling mechanisms and their implications in disease.