CUL4B抗体;CUL4B Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P11693(CUL4B Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P11693(CUL4B Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The CUL4B antibody is a research tool used to study the Cullin 4B (CUL4B) protein, a core component of the Cullin-RING E3 ubiquitin ligase complex (CRL4B). CUL4B, encoded by the *CUL4B* gene on the X chromosome, functions as a scaffold protein that assembles with DDB1. ROC1. and substrate receptors to mediate substrate-specific ubiquitination. This post-translational modification regulates diverse cellular processes, including DNA repair, chromatin remodeling, cell cycle progression, and transcriptional regulation. Dysregulation of CUL4B has been linked to X-linked intellectual disability syndromes (e.g., Cabezas syndrome) and cancers, where its overexpression may promote tumorigenesis by destabilizing tumor suppressors or cell cycle inhibitors.

CUL4B antibodies are essential for detecting protein expression, localization, and interactions in experimental techniques like Western blotting, immunohistochemistry, and immunoprecipitation. They help elucidate CUL4B’s role in disease mechanisms and its interplay with other ubiquitination pathway components. Specificity and validation of these antibodies are critical, as CUL4B shares structural homology with other Cullin family members (e.g., CUL4A). Research using CUL4B antibodies has advanced understanding of its dual roles in neurodevelopment and cancer, highlighting potential therapeutic targets. However, challenges remain in distinguishing isoform-specific functions and developing clinical applications.