CSTB抗体,Rabbit Polyclonal CSTB Antibody
  • CSTB抗体,Rabbit Polyclonal CSTB Antibody
  • CSTB抗体,Rabbit Polyclonal CSTB Antibody
  • CSTB抗体,Rabbit Polyclonal CSTB Antibody

CSTB抗体;CSTB Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-26
QQ交谈 微信洽谈

产品详情

中文名称:CSTB抗体英文名称:Rabbit Polyclonal CSTB Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 6210 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: CSTB
2025-05-26 CSTB抗体 Rabbit Polyclonal CSTB Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 6210 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesPME; ULD; CST6; EPM1; STFB; EPM1A
WB Predicted band size11 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human CSTB
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 10+12%SDS-PAGE, Lysate: 40 μg, Lane: Mouse spleen tissue, Primary antibody: P11698(CSTB Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2.5 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human brain tissue using P11698(CSTB Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P11698(CSTB Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于CSTB抗体的3篇参考文献示例(内容基于公开研究总结,非真实文献,仅供参考):

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1. **文献名称**: *Cystatin B (CSTB) deficiency drives neurodegeneration in a mouse model of Unverricht-Lundborg disease*

**作者**: Joensuu T, et al.

**摘要**: 研究利用CSTB基因敲除小鼠模型,揭示CSTB蛋白缺失导致神经元退行性变和癫痫表型,并通过CSTB抗体检测发现其在小脑颗粒细胞中的表达异常,提示CSTB在维持神经元稳态中的关键作用。

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2. **文献名称**: *Immunohistochemical analysis of CSTB in progressive myoclonus epilepsy type 1 (EPM1) patients*

**作者**: Alakurtti K, et al.

**摘要**: 通过CSTB特异性抗体对EPM1患者脑组织进行免疫组化分析,发现CSTB蛋白表达显著降低,且与疾病严重程度相关,支持CSTB功能缺失是EPM1的核心病理机制。

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3. **文献名称**: *Development of a high-affinity monoclonal antibody for human cystatin B detection*

**作者**: Riccio M, et al.

**摘要**: 报道了一种新型CSTB单克隆抗体的开发与验证,该抗体在ELISA和Western blot中表现出高特异性和灵敏度,为临床诊断CSTB相关疾病提供了可靠工具。

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4. **文献名称**: *CSTB interacts with autophagy proteins: Implications for neurodegeneration*

**作者**: Houseweart MK, et al.

**摘要**: 研究通过免疫共沉淀结合CSTB抗体发现CSTB与自噬通路蛋白的相互作用,提出其在调控神经元自噬中的潜在作用,为神经退行性疾病机制提供了新视角。

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如需真实文献,建议通过PubMed或Google Scholar检索关键词:*CSTB antibody*、*cystatin B neurodegeneration*、*EPM1 pathogenesis*。

       

背景信息

CSTB (Cystatin B) is a small, ubiquitously expressed protein belonging to the cystatin superfamily of cysteine protease inhibitors. It primarily regulates the activity of lysosomal cathepsins, enzymes involved in protein degradation, by binding to their active sites. Dysregulation of CSTB has been linked to several pathological conditions, most notably Unverricht-Lundborg disease (EPM1), a rare inherited progressive myoclonus epilepsy caused by mutations in the CSTB gene. Loss-of-function mutations lead to reduced CSTB levels, resulting in uncontrolled protease activity, neuroinflammation, and neuronal apoptosis.

CSTB antibodies are essential tools in studying its expression, localization, and functional roles. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess CSTB protein levels in tissues or cell cultures, particularly in neurological research. These antibodies help elucidate mechanisms underlying EPM1 and other disorders associated with CSTB dysfunction, such as cancer and neurodegenerative diseases. Commercial CSTB antibodies are typically raised against specific epitopes of human CSTB and validated for cross-reactivity in model organisms like mice and rats. Recent studies also explore CSTB's non-canonical roles, including its involvement in autophagy and oxidative stress response, further highlighting the antibody's utility in diverse research contexts.

       
关键字: CSTB抗体;CSTB;CSTB Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

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