ELOVL6抗体;ELOVL6 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P11733(ELOVL6 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P11733(ELOVL6 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The ELOVL6 antibody is a research tool designed to study the function and expression of ELOVL6 (Elongation of Very Long-Chain Fatty Acids Protein 6), a key enzyme in fatty acid metabolism. ELOVL6 catalyzes the elongation of C16 saturated and monounsaturated fatty acids to C18 species, a critical step in de novo lipogenesis. It is highly expressed in tissues with active lipid synthesis, such as the liver, adipose tissue, and pancreas, and plays a role in regulating metabolic homeostasis, insulin sensitivity, and cellular lipid composition. Dysregulation of ELOVL6 has been linked to metabolic disorders, including obesity, type 2 diabetes, and non-alcoholic fatty liver disease (NAFLD), as well as certain cancers, where altered lipid metabolism supports tumor growth.

ELOVL6 antibodies are primarily used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect protein expression levels, cellular localization, and tissue distribution. These antibodies aid in exploring ELOVL6's role in disease mechanisms, such as its contribution to hepatic steatosis or insulin resistance in preclinical models. Additionally, they support drug discovery efforts targeting lipid metabolism pathways. Validation of ELOVL6 antibodies includes specificity testing via knockout controls and cross-reactivity assessments. Given the enzyme's conserved role across species, such antibodies are valuable in translational studies bridging rodent models and human diseases.