GAS1抗体,Rabbit Polyclonal GAS1 Antibody
  • GAS1抗体,Rabbit Polyclonal GAS1 Antibody
  • GAS1抗体,Rabbit Polyclonal GAS1 Antibody
  • GAS1抗体,Rabbit Polyclonal GAS1 Antibody

GAS1抗体;GAS1 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-26
QQ交谈 微信洽谈

产品详情

中文名称:GAS1抗体英文名称:Rabbit Polyclonal GAS1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 6258 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: GAS1
2025-05-26 GAS1抗体 Rabbit Polyclonal GAS1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 6258 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/10-1/50 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

WB Predicted band size36 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human GAS1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: 293T cells, human kidney tissue, Primary antibody: P11780(GAS1 Antibody) at dilution 1/100, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P11780(GAS1 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是关于GAS1抗体的3篇参考文献及其简要摘要:

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1. **标题**: *GAS1 inhibits cell proliferation and induces apoptosis in human hepatocellular carcinoma via the Hedgehog signaling pathway*

**作者**: Martinelli, R. et al.

**摘要**: 本研究通过Western blot和免疫组化实验,使用GAS1抗体检测肝癌细胞中GAS1蛋白的表达。结果表明,GAS1通过抑制Hedgehog通路抑制肿瘤细胞增殖并促进凋亡,提示其作为潜在治疗靶点。

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2. **标题**: *Growth Arrest-Specific 1 (GAS1) is a Critical Regulator of Neural Stem Cell Differentiation*

**作者**: Schneider, S. et al.

**摘要**: 研究利用GAS1抗体进行免疫荧光染色,发现GAS1在小鼠神经干细胞中高表达,并通过调控Retinoic Acid信号通路促进分化,为神经发育机制提供了新见解。

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3. **标题**: *GAS1 interacts with PTCH1 to regulate Sonic Hedgehog signaling in development*

**作者**: Allen, B.L. et al.

**摘要**: 通过免疫共沉淀(Co-IP)和免疫印迹实验,验证GAS1与PTCH1的相互作用。研究揭示GAS1作为Hedgehog信号通路的共受体,影响胚胎发育过程中的细胞命运决定。

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**备注**:以上文献信息为示例性质,实际引用时建议通过PubMed或Google Scholar核对准确标题及作者。若需具体文献,可进一步提供研究方向(如疾病模型、实验技术等)。

       

背景信息

The Growth Arrest-Specific 1 (GAS1) protein is a cell membrane-associated molecule initially identified in fibroblasts during growth arrest. It plays a critical role in regulating cell proliferation, differentiation, and survival, primarily by modulating key signaling pathways such as Hedgehog (Hh) and glial cell line-derived neurotrophic factor (GDNF) signaling. GAS1 acts as a co-receptor, enhancing Hh pathway activity by binding to the receptor Patched-1 (PTCH1), while paradoxically inhibiting GDNF signaling by interfering with the RET receptor tyrosine kinase. Its dual regulatory function makes it pivotal in embryonic development, tissue homeostasis, and cancer progression.

GAS1 antibodies are essential tools for detecting and studying the expression, localization, and functional roles of GAS1 in both physiological and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate GAS1's involvement in neurodevelopment, organogenesis, and diseases such as cancer, where its expression is often dysregulated. Research has also explored GAS1's potential as a therapeutic target, particularly in tumors reliant on Hh or GDNF signaling. However, its context-dependent roles—acting as either a tumor suppressor or promoter—highlight the need for precise characterization using specific antibodies to unravel its complex biological mechanisms.

       
关键字: GAS1抗体;GAS1;GAS1 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

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