GLS抗体,Rabbit Polyclonal GLS Antibody
  • GLS抗体,Rabbit Polyclonal GLS Antibody
  • GLS抗体,Rabbit Polyclonal GLS Antibody
  • GLS抗体,Rabbit Polyclonal GLS Antibody

GLS抗体;GLS Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-26
QQ交谈 微信洽谈

产品详情

中文名称:GLS抗体英文名称:Rabbit Polyclonal GLS Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 6264 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: GLS
2025-05-26 GLS抗体 Rabbit Polyclonal GLS Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 6264 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesGAC; GAM; KGA; GLS1; AAD20
WB Predicted band size73 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human GLS
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: 293T cell lysate, Primary antibody: P11792(GLS Antibody) at dilution 1/850, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P11792(GLS Antibody) at dilution 1/70. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P11792(GLS Antibody) at dilution 1/70. (Original magnification: ×200)    


           

参考文献

以下是关于GLS(谷氨酰胺酶)抗体的3篇虚构参考文献示例,结构符合您的要求:

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1. **文献名称**:*Glutaminase 1 (GLS1) Antibody Validation in Tumor Tissue Immunohistochemistry*

**作者**:Altman, J.R., et al.

**摘要**:本研究通过免疫组化技术验证了GLS1抗体在多种肿瘤组织中的特异性表达,发现其与肿瘤代谢重编程及患者预后显著相关。抗体特异性通过siRNA敲低实验确认,为临床检测GLS1表达提供可靠工具。

2. **文献名称**:*Isoform-Specific Roles of GLS in Breast Cancer: GAC vs. KGA*

**作者**:Thompson, L.M., et al.

**摘要**:文章比较了GLS两种剪接变体(GAC和KGA)在乳腺癌中的差异表达,利用特异性抗体通过Western blot分析发现,GAC高表达与侵袭性表型相关,提示其作为治疗靶点的潜力。

3. **文献名称**:*Targeting Glutaminase with CB-839: Antibody-Based Monitoring of Enzyme Inhibition*

**作者**:Roberts, S.K., et al.

**摘要**:研究报道了GLS抑制剂CB-839在肺癌模型中的疗效,通过定制GLS抗体监测抑制剂对酶活性的影响,证实抗体在药效评估中的应用价值。

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(注:以上文献为示例性虚构内容,实际研究需通过PubMed/Google Scholar等平台检索关键词如“Glutaminase antibody”、“GLS1 validation”获取真实文献。)

       

背景信息

Glutaminase (GLS) antibodies are essential tools for studying the role of glutaminase enzymes, which catalyze the hydrolysis of glutamine to glutamate—a critical step in cellular metabolism. Glutaminase exists as two primary isoforms: GLS1 (kidney-type) and GLS2 (liver-type). GLS1 is ubiquitously expressed and plays a key role in cancer cell metabolism by supporting the tricarboxylic acid (TCA) cycle and nucleotide biosynthesis, making it a focal point in oncology research. GLS2. though less characterized, is implicated in antioxidant defense and is often downregulated in certain cancers but upregulated in others, such as hepatocellular carcinoma.

GLS antibodies are widely used in immunoblotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess protein expression, localization, and regulation in both physiological and pathological contexts. Their application spans cancer research, neurodegenerative diseases (e.g., Alzheimer’s), and metabolic disorders, where dysregulated glutaminolysis is observed. Notably, GLS1 inhibitors are under clinical investigation as anticancer agents, driving demand for reliable antibodies to validate target engagement and therapeutic efficacy. However, challenges remain in isoform specificity, as cross-reactivity between GLS1 splice variants (e.g., KGA vs. GAC) or GLS2 can complicate data interpretation. Recent advances in antibody validation techniques, including CRISPR-based knockout controls, have improved reliability. These reagents continue to support discoveries linking glutamine metabolism to cell proliferation, redox homeostasis, and disease progression.

       
关键字: GLS抗体;GLS;GLS Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

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