LPP抗体;LPP Antibody—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: HepG2 cells, Primary antibody: P11913(LPP Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P11913(LPP Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

LPP (LIM domain-containing preferred translocation partner in lipoma) is a protein encoded by the LPP gene, initially identified due to its involvement in chromosomal translocations in benign mesenchymal tumors, particularly lipomas. It belongs to the zyxin family of proteins, characterized by LIM domains that mediate protein-protein interactions and focal adhesion localization. LPP plays roles in cell adhesion, migration, and transcriptional regulation by shuttling between the cytoplasm and nucleus. It interacts with cytoskeletal components and signaling molecules, influencing pathways like TGF-β and Hippo, which are critical in cancer progression and metastasis.

LPP antibodies are essential tools for studying its expression, localization, and function in physiological and pathological contexts. In research, these antibodies help detect LPP overexpression or aberrant localization in cancers, including sarcoma, breast, and ovarian cancers, where LPP may act as an oncogene or tumor suppressor depending on context. They also aid in investigating LPP’s role in tumorigenesis through chromosomal rearrangements, such as the recurrent t(3;12) translocation forming the HMGA2-LPP fusion gene in lipomas. Clinically, LPP antibodies have potential diagnostic utility in identifying translocation-driven tumors or monitoring metastasis-related pathways. Commercial LPP antibodies are typically validated for techniques like Western blot, immunohistochemistry, and immunofluorescence, enabling multifaceted exploration of its dual roles in cell motility and gene regulation.