SMC6抗体,Rabbit Polyclonal SMC6 Antibody
  • SMC6抗体,Rabbit Polyclonal SMC6 Antibody
  • SMC6抗体,Rabbit Polyclonal SMC6 Antibody
  • SMC6抗体,Rabbit Polyclonal SMC6 Antibody

SMC6抗体;SMC6 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-26
QQ交谈 微信洽谈

产品详情

中文名称:SMC6抗体英文名称:Rabbit Polyclonal SMC6 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 6515 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: SMC6
2025-05-26 SMC6抗体 Rabbit Polyclonal SMC6 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 6515 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/20-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesSMC-6; hSMC6; SMC6L1
WB Predicted band size126 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human SMC6
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

  •  

     

       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Jurkat cells, 231 cells, hela cells, 293T cells, Primary antibody: P12218(SMC6 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human brain tissue using P12218(SMC6 Antibody) at dilution 1/20. (Original magnification: ×200)    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P12218(SMC6 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是关于SMC6抗体的3篇参考文献示例(文献信息为虚构,仅用于示例格式):

---

1. **文献名称**: "The SMC5/6 complex regulates replication fork stability via recruitment of DNA repair factors"

**作者**: Martinez A, et al.

**摘要**: 本研究利用SMC6特异性抗体,通过免疫沉淀和质谱分析,揭示了SMC5/6复合体在DNA复制压力下招募FANCD2和RAD51等修复蛋白至停滞复制叉的机制,证明其通过维持复制叉完整性防止基因组断裂。

---

2. **文献名称**: "SMC6 deficiency promotes chromosomal instability and sensitizes cancer cells to PARP inhibitors"

**作者**: Chen L, et al.

**摘要**: 通过SMC6抗体进行免疫荧光和Western blot实验,发现SMC6敲除导致癌细胞染色体错误分离和微核形成增加,并增强PARP抑制剂敏感性,提示SMC6缺失可能作为癌症治疗的潜在生物标志物。

---

3. **文献名称**: "Development and validation of a novel SMC6 monoclonal antibody for functional studies in meiosis"

**作者**: Tanaka R, et al.

**摘要**: 本文报道了一种高特异性小鼠抗人SMC6单克隆抗体的开发,验证其在免疫组化、流式细胞术中的应用,并发现SMC6在减数分裂粗线期染色体轴组装中的关键作用。

---

(注:以上文献为示例性内容,实际引用需以真实发表研究为准。)

       

背景信息

The SMC6 antibody targets the Structural Maintenance of Chromosomes 6 (SMC6) protein, a key component of the SMC5/6 complex involved in maintaining genomic stability. SMC6. along with SMC5. forms a heterodimer critical for DNA repair, chromosome segregation, and replication fork stability. This complex facilitates homologous recombination repair (HRR) of DNA double-strand breaks and resolves replication-associated topological stress, ensuring faithful chromosome transmission during cell division. Dysregulation of SMC6 is linked to chromosomal aberrations, replication errors, and diseases like cancer.

SMC6 antibodies are widely used in research to study DNA damage response mechanisms, replication stress, and mitotic regulation. They enable detection of SMC6 expression, localization, and interaction partners via techniques such as Western blotting, immunofluorescence, and co-immunoprecipitation. Studies using these antibodies have revealed SMC6's role in safeguarding replication forks in BRCA-deficient cancers and its potential as a therapeutic target. Commercial SMC6 antibodies are typically validated in model systems (e.g., human, mouse) to ensure specificity, with applications spanning basic chromatin biology to translational cancer research. Ongoing studies explore its interplay with cohesin and condensin complexes in 3D genome organization.

       
关键字: SMC6抗体;SMC6;SMC6 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

SMC6抗体;SMC6 Antibody—艾普蒂相关厂家报价

产品名称 价格   公司名称 报价日期
询价
VIP5年
上海冠导生物工程有限公司
2026-02-08
¥960.00
VIP10年
北京索莱宝科技有限公司
2026-02-06
询价
上海华盈生物医药科技有限公司
2026-01-29
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
内容声明:
以上所展示的信息由商家自行提供,内容的真实性、准确性和合法性由发布商家负责。 商家发布价格指该商品的参考价格,并非原价,该价格可能随着市场变化,或是由于您购买数量不同或所选规格不同而发生变化。最终成交价格,请咨询商家,以实际成交价格为准。请意识到互联网交易中的风险是客观存在的
主页 | 企业会员服务 | 广告业务 | 联系我们 | 旧版入口 | 中文MSDS | CAS Index | 常用化学品CAS列表 | 化工产品目录 | 新产品列表 |投诉中心
Copyright © 2008 ChemicalBook 京ICP备07040585号  京公海网安备110108000080号  All rights reserved.