ABCC1抗体,Rabbit Polyclonal ABCC1 Antibody
  • ABCC1抗体,Rabbit Polyclonal ABCC1 Antibody
  • ABCC1抗体,Rabbit Polyclonal ABCC1 Antibody
  • ABCC1抗体,Rabbit Polyclonal ABCC1 Antibody

ABCC1抗体;ABCC1 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-26
QQ交谈 微信洽谈

产品详情

中文名称:ABCC1抗体英文名称:Rabbit Polyclonal ABCC1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 6673 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: ABCC1
2025-05-26 ABCC1抗体 Rabbit Polyclonal ABCC1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 6673 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesMRP; ABCC; GS-X; MRP1; ABC29
WB Predicted band size172 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human ABCC1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: A431 cell, Primary antibody: P12470(ABCC1 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P12470(ABCC1 Antibody) at dilution 1/25. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P12470(ABCC1 Antibody) at dilution 1/25. (Original magnification: ×200)    


           

参考文献

以下是关于ABCC1抗体的3篇示例参考文献(基于学术文献的常见研究方向,内容为示例性概括):

1. **文献名称**:*Characterization of monoclonal antibodies against human ABCC1 (MRP1) and their application in detecting MRP overexpression in cancer cells*

**作者**:Deeley, R.G., et al.

**摘要**:研究报道了针对ABCC1蛋白不同表位的单克隆抗体的开发与验证,通过免疫印迹和免疫组化证实其在多种耐药性癌细胞系中的高表达,为ABCC1在肿瘤多药耐药性中的作用提供实验依据。

2. **文献名称**:*Comparative analysis of ABCC1 antibody specificity in human tissues using immunohistochemistry*

**作者**:Létourneau, I.J., et al.

**摘要**:比较了不同商业来源的ABCC1抗体在正常及病理组织中的特异性,发现某些抗体存在交叉反应性,提出标准化验证流程以提高实验可靠性,尤其在肝脏和肾脏组织中的应用需谨慎。

3. **文献名称**:*ABCC1-mediated efflux in neurological disorders: Antibody-based localization in brain endothelial cells*

**作者**:Hartz, A.M.S., et al.

**摘要**:利用ABCC1特异性抗体进行免疫荧光染色,揭示其在血脑屏障内皮细胞中的极性分布,提示其在限制神经毒素积累中的作用,为阿尔茨海默病等疾病的治疗靶点研究提供依据。

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注:以上文献为示例性内容,实际引用时建议通过PubMed或Web of Science检索最新研究,并核对作者及摘要准确性。

       

背景信息

ABCC1 (ATP-binding cassette subfamily C member 1), also known as multidrug resistance-associated protein 1 (MRP1), is a transmembrane transporter belonging to the ABC protein superfamily. It plays a critical role in cellular detoxification by effluxing a wide range of endogenous and exogenous compounds, including glutathione-conjugated metabolites, anticancer drugs (e.g., vinca alkaloids, anthracyclines), and organic anions. ABCC1 is expressed in various tissues, such as the liver, kidneys, lungs, and blood-brain barrier, and its overexpression is linked to multidrug resistance in cancer chemotherapy.

ABCC1 antibodies are essential tools for studying its expression, localization, and function in physiological and pathological contexts. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess ABCC1 levels in cancer cells, normal tissues, or experimental models. Specific monoclonal or polyclonal antibodies target distinct epitopes (e.g., cytoplasmic domains or extracellular loops) to ensure detection specificity. Validated antibodies help investigate ABCC1's role in drug resistance mechanisms, cellular stress responses, and disease progression. Additionally, they aid in evaluating ABCC1 as a potential biomarker or therapeutic target. Researchers must verify antibody specificity using knockout controls or blocking peptides to avoid cross-reactivity with homologous ABC transporters like ABCC2 or ABCC3.

       
关键字: ABCC1抗体;ABCC1;ABCC1 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

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