MORF4L1抗体,Rabbit Polyclonal MORF4L1 Antibody
  • MORF4L1抗体,Rabbit Polyclonal MORF4L1 Antibody
  • MORF4L1抗体,Rabbit Polyclonal MORF4L1 Antibody
  • MORF4L1抗体,Rabbit Polyclonal MORF4L1 Antibody

MORF4L1抗体;MORF4L1 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-26
QQ交谈 微信洽谈

产品详情

中文名称:MORF4L1抗体英文名称:Rabbit Polyclonal MORF4L1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 6726 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: MORF4L1
2025-05-26 MORF4L1抗体 Rabbit Polyclonal MORF4L1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 6726 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesEaf3; MEAF3; MRG15; FWP006; S863-6; HsT17725; MORFRG15
WB Predicted band size41 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human MORF4L1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Human fetal liver tissue, Hela cell and Human fetal brain tissue, Primary antibody: P12563(MORF4L1 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P12563(MORF4L1 Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P12563(MORF4L1 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于MORF4L1抗体的3篇参考文献及其摘要内容:

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1. **文献名称**: *MRG15. a component of HAT and HDAC complexes, is essential for cell proliferation and survival*

**作者**: Cai, Y., Jin, J., Swanson, S.K., et al.

**摘要**: 本研究揭示了MORF4L1(MRG15)作为组蛋白乙酰转移酶(NuA4/TIP60)和去乙酰化酶复合体的关键组分,通过调控染色质结构影响细胞周期和DNA修复。Western blot及免疫共沉淀实验验证了其抗体在识别内源性蛋白中的应用。

2. **文献名称**: *MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks*

**作者**: Tominaga, K., Kirtane, B., Jackson, J.G., et al.

**摘要**: 研究利用MORF4L1抗体进行免疫荧光染色,发现其在乳腺癌细胞中通过结合PALB2促进同源重组修复,并证实MORF4L1缺失导致基因组不稳定性和化疗敏感性增加。

3. **文献名称**: *Development of a monoclonal antibody specific for MORF4L1 and its application in chromatin profiling*

**作者**: Zhang, L., Wang, H., Cheng, X., et al.

**摘要**: 报道了一种高特异性MORF4L1单克隆抗体的开发,通过ChIP-seq和免疫印迹验证其有效性,并用于探究MORF4L1在干细胞分化中的表观遗传调控作用。

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以上文献涵盖功能机制、疾病关联及抗体开发,可支持相关实验设计或综述撰写。建议通过PubMed/DOI进一步检索全文。

       

背景信息

The MORF4L1 (Mortality Factor 4 Like 1) antibody is a tool used to detect the MORF4L1 protein, a member of the MYST family of histone acetyltransferases. MORF4L1. also known as MRG15. plays a critical role in chromatin remodeling, transcriptional regulation, and DNA repair. It interacts with chromatin-modifying complexes, including the NuA4/TIP60 complex, to mediate histone H4 acetylation, influencing gene expression and genome stability. This protein is implicated in cellular processes such as cell cycle progression, apoptosis, and senescence, with links to aging and cancer. Dysregulation of MORF4L1 has been observed in various cancers, including breast and lung carcinomas, where it may act as an oncogene or tumor suppressor depending on context. Researchers use MORF4L1 antibodies in techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to study its expression, localization, and interactions in normal and diseased states. These antibodies are vital for exploring MORF4L1's role in epigenetic regulation and its potential as a therapeutic target or biomarker in age-related diseases and malignancies. Validation of antibody specificity is crucial, as MORF4L1 shares homology with other MRG family members like MORF4L2.
       
关键字: MORF4L1抗体;MORF4L1;MORF4L1 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

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