**Background of HOXB9 Antibody**
HOXB9. a member of the Homeobox (HOX) gene family, encodes a transcription factor critical in embryonic development, particularly in establishing body patterning and tissue differentiation. HOX proteins regulate gene expression by binding to DNA, influencing cellular identity and morphogenesis. HOXB9 is notably involved in mammary gland development, hematopoiesis, and angiogenesis.
In cancer research, HOXB9 has gained attention due to its aberrant expression in malignancies like breast, lung, and colorectal cancers. Overexpression of HOXB9 is linked to tumor progression, metastasis, and therapy resistance, partly through promoting epithelial-mesenchymal transition (EMT) and angiogenesis. Its role in maintaining cancer stem cell properties further highlights its oncogenic potential.
HOXB9 antibodies are essential tools for detecting HOXB9 protein levels and localization in cells and tissues. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study HOXB9's biological functions and mechanisms in development and disease. Researchers also employ HOXB9 antibodies to explore its prognostic value in cancers or its interaction with regulatory pathways, aiding in the identification of therapeutic targets.
Overall, HOXB9 antibodies serve as vital reagents in both basic and translational research, bridging developmental biology and oncology.