MIF抗体,Rabbit Polyclonal MIF Antibody
  • MIF抗体,Rabbit Polyclonal MIF Antibody
  • MIF抗体,Rabbit Polyclonal MIF Antibody
  • MIF抗体,Rabbit Polyclonal MIF Antibody

MIF抗体;MIF Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-27
QQ交谈 微信洽谈

产品详情

中文名称:MIF抗体英文名称:Rabbit Polyclonal MIF Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 6847 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: MIF
2025-05-27 MIF抗体 Rabbit Polyclonal MIF Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 6847 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesGIF; GLIF; MMIF
WB Predicted band size12 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human MIF
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-4: HT-29, Hela and Jurkat cell, Rat brain tissue lysates, Primary antibody: P12789(MIF Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 50 seconds    


           

参考文献

以下是关于MIF(巨噬细胞移动抑制因子)抗体的示例性参考文献(均为模拟内容,供参考格式):

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1. **文献名称**: *Targeting MIF in Inflammatory Diseases: Mechanistic Insights and Therapeutic Potential*

**作者**: Bucala R, et al.

**摘要**: 该综述总结了MIF在炎症性疾病(如败血症、类风湿性关节炎)中的核心作用,重点探讨了抗MIF抗体通过阻断MIF与受体CD74的结合来抑制促炎信号通路的机制,并展望了其在临床治疗中的应用前景。

2. **文献名称**: *Anti-MIF Antibody Attenuates Tumor Growth and Metastasis in Colorectal Cancer Models*

**作者**: Simpson KD, et al.

**摘要**: 研究显示,抗MIF抗体可通过抑制肿瘤微环境中MIF介导的血管生成和免疫逃逸,显著减少结直肠癌小鼠模型的肿瘤体积和肝转移,提示其作为癌症靶向治疗的潜力。

3. **文献名称**: *MIF Neutralization with Monoclonal Antibodies Ameliorates Experimental Autoimmune Encephalomyelitis*

**作者**: Santos LL, Morand EF.

**摘要**: 在多发性硬化症动物模型中,抗MIF单克隆抗体通过下调Th17细胞分化和血脑屏障破坏,减轻神经炎症和髓鞘损伤,为自身免疫疾病的抗体治疗提供了实验依据。

4. **文献名称**: *Development of a High-Sensitivity MIF ELISA for Prognostic Evaluation in Sepsis*

**作者**: Calandra T, et al.

**摘要**: 研究团队开发了一种基于抗MIF抗体的高灵敏度检测方法,证实脓毒症患者血清MIF水平与器官衰竭严重程度和死亡率显著相关,提示其作为生物标志物的临床应用价值。

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**备注**:以上文献为示例,实际文献需通过PubMed、Web of Science等学术平台检索关键词“MIF antibody”或“Macrophage Migration Inhibitory Factor therapeutics”获取。

       

背景信息

Macrophage Migration Inhibitory Factor (MIF) is a multifunctional cytokine first identified in the 1960s for its ability to inhibit the random migration of macrophages. Over time, MIF has been recognized as a critical regulator of innate and adaptive immunity, inflammation, and cell proliferation. It is secreted by various immune cells, including macrophages, T cells, and endothelial cells, and acts through receptors such as CD74. CXCR2. and CXCR4. MIF exhibits unique enzymatic activity (e.g., tautomerase) and plays dual roles in health and disease, promoting pro-inflammatory responses while also contributing to tissue repair. Dysregulated MIF expression is implicated in autoimmune diseases (e.g., rheumatoid arthritis, lupus), sepsis, cancer, and metabolic disorders, making it a therapeutic target.

MIF antibodies, including monoclonal and polyclonal variants, are essential tools for research and potential clinical applications. They enable detection of MIF in biological samples, inhibition of its signaling pathways, and exploration of its pathological mechanisms. Therapeutic anti-MIF antibodies aim to neutralize its pro-inflammatory or tumor-promoting effects, with preclinical studies showing promise in reducing disease severity in models of inflammation and cancer. However, challenges remain in balancing MIF's beneficial roles (e.g., antimicrobial defense) versus its pathological contributions. Ongoing research focuses on optimizing antibody specificity, delivery, and safety to advance MIF-targeted therapies into clinical trials.

       
关键字: MIF抗体;MIF;MIF Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
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