B3GNT3抗体,Rabbit Polyclonal B3GNT3 Antibody
  • B3GNT3抗体,Rabbit Polyclonal B3GNT3 Antibody
  • B3GNT3抗体,Rabbit Polyclonal B3GNT3 Antibody
  • B3GNT3抗体,Rabbit Polyclonal B3GNT3 Antibody

B3GNT3抗体;B3GNT3 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-27
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产品详情

中文名称:B3GNT3抗体英文名称:Rabbit Polyclonal B3GNT3 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 6950 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: B3GNT3
2025-05-27 B3GNT3抗体 Rabbit Polyclonal B3GNT3 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 6950 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesTMEM3; B3GN-T3; B3GNT-3; HP10328; B3GAL-T8; beta3Gn-T3
WB Predicted band size43 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human B3GNT3
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hela and 293T cell lysates, Primary antibody: P12936(B3GNT3 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P12936(B3GNT3 Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P12936(B3GNT3 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于B3GNT3抗体的3篇参考文献示例(文献信息为虚构模拟,仅供格式参考):

1. **文献名称**:*B3GNT3 regulates colorectal cancer metastasis through glycosylation of CD147*

**作者**:Li Y, Wang X, et al.

**摘要**:该研究利用B3GNT3特异性抗体,发现其在结直肠癌中高表达,并通过糖基化修饰CD147蛋白促进肿瘤侵袭转移。抗体用于免疫组化验证临床样本中的蛋白定位。

2. **文献名称**:*Antibody-based targeting of B3GNT3 suppresses tumor growth in ovarian cancer models*

**作者**:Chen H, Zhang R, et al.

**摘要**:开发了一种针对B3GNT3的单克隆抗体,体外实验显示其可阻断细胞表面聚糖结构异常,抑制卵巢癌细胞增殖并诱导凋亡,动物模型验证了抗体的治疗潜力。

3. **文献名称**:*B3GNT3-mediated glycosylation in T cell immunity: Insights from knockout mice*

**作者**:Smith J, Tanaka K, et al.

**摘要**:通过B3GNT3抗体检测基因敲除小鼠的淋巴细胞,发现该酶缺失导致T细胞受体糖基化异常,削弱免疫突触形成,提示其在适应性免疫中的关键作用。

(注:以上内容为模拟生成,实际文献需通过学术数据库检索确认。)

       

背景信息

The B3GNT3 antibody targets the β-1.3-N-acetylglucosaminyltransferase 3 (B3GNT3), a glycosyltransferase enzyme involved in synthesizing poly-N-acetyllactosamine (poly-LacNAc) chains on glycoproteins and glycolipids. B3GNT3 catalyzes the transfer of N-acetylglucosamine (GlcNAc) to terminal galactose residues via a β1.3-linkage, a critical step in extending carbohydrate structures implicated in cell adhesion, signaling, and immune recognition. This enzyme is particularly associated with cancer progression, as elevated B3GNT3 expression has been observed in malignancies like colorectal, breast, and ovarian cancers. It contributes to metastasis by facilitating the synthesis of E-selectin ligands, which promote tumor cell adhesion to endothelial cells during hematogenous spread.

B3GNT3 antibodies are essential tools for studying its role in glycosylation-dependent pathological processes. They enable detection and localization of B3GNT3 in tissues or cell lines via techniques such as Western blotting, immunohistochemistry (IHC), or flow cytometry. Research using these antibodies has highlighted B3GNT3's potential as a biomarker for aggressive tumors and a therapeutic target. Inhibiting B3GNT3 activity or expression has shown promise in reducing cancer cell invasiveness in preclinical models. Additionally, B3GNT3 antibodies aid in exploring its regulatory mechanisms, including transcriptional control by oncogenic signaling pathways, further linking aberrant glycosylation to tumor biology.

       
关键字: B3GNT3抗体;B3GNT3;B3GNT3 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

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