The EVX1 antibody is a crucial tool in developmental biology and cancer research, targeting the Even-spliced Homeobox 1 (EVX1) protein encoded by the EVX1 gene. EVX1. a member of the homeobox gene family, acts as a transcription factor regulating embryonic development, particularly in anterior-posterior patterning, limb formation, and nervous system organization. Its expression is tightly controlled during embryogenesis, with roles in cell differentiation and tissue morphogenesis.
In adulthood, EVX1 exhibits restricted expression but has been implicated in several cancers, including colorectal, gastric, and prostate malignancies, where it may function as either an oncogene or tumor suppressor depending on context. The EVX1 antibody enables detection and localization of EVX1 protein in cells and tissues, facilitating studies on its expression dynamics, molecular interactions, and post-translational modifications.
Researchers employ this antibody in techniques like immunohistochemistry, Western blotting, and immunofluorescence to investigate EVX1's involvement in developmental disorders, cancer progression, and potential therapeutic applications. Recent studies also explore its role in stem cell regulation and regenerative processes. Specific validation parameters for the antibody (e.g., host species, clonality, and epitope information) vary by commercial source, requiring careful selection for experimental needs.