The ZNF560 antibody is a research tool designed to target the zinc finger protein 560 (ZNF560), a member of the Krüppel-associated box (KRAB) domain-containing zinc finger protein family. These proteins are characterized by tandem C2H2-type zinc finger motifs, which facilitate sequence-specific DNA binding, and a KRAB domain that often mediates transcriptional repression by recruiting chromatin-modifying complexes. ZNF560 is hypothesized to play roles in gene regulation, particularly in developmental processes, cell differentiation, or stress responses, though its precise biological functions remain under investigation.
The antibody is typically produced in hosts such as rabbits or mice using immunogenic peptides or recombinant protein fragments corresponding to specific epitopes of ZNF560. It is widely utilized in techniques like Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF) to detect ZNF560 expression levels, localization, and interactions in cellular or tissue samples. Validation often includes checks for specificity via knockdown/knockout controls or cross-reactivity assessments.
Studies involving ZNF560 antibodies aim to clarify its involvement in diseases such as cancer, neurological disorders, or autoimmune conditions, where aberrant zinc finger protein activity has been implicated. However, comprehensive mechanistic insights into ZNF560’s pathways are still emerging, highlighting the importance of reliable antibodies for ongoing research. Commercial variants may vary in clonality (monoclonal/polyclonal), conjugates (e.g., HRP, fluorescent tags), and species reactivity, necessitating context-specific selection.