HNRNPUL1抗体,Rabbit Polyclonal HNRNPUL1 Antibody
  • HNRNPUL1抗体,Rabbit Polyclonal HNRNPUL1 Antibody
  • HNRNPUL1抗体,Rabbit Polyclonal HNRNPUL1 Antibody
  • HNRNPUL1抗体,Rabbit Polyclonal HNRNPUL1 Antibody

HNRNPUL1抗体;HNRNPUL1 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-28
QQ交谈 微信洽谈

产品详情

中文名称:HNRNPUL1抗体英文名称:Rabbit Polyclonal HNRNPUL1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 7383 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: HNRNPUL1
2025-05-28 HNRNPUL1抗体 Rabbit Polyclonal HNRNPUL1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 7383 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/200-1/1000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/30-1/150 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesE1BAP5; E1B-AP5; HNRPUL1
WB Predicted band size96 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human HNRNPUL1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Hela, 231 and Raji cell lysates, Primary antibody: P13587(HNRNPUL1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P13587(HNRNPUL1 Antibody) at dilution 1/20. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P13587(HNRNPUL1 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是3篇与HNRNPUL1抗体相关的文献信息(基于真实文献的模拟简化版,供参考):

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1. **文献名称**: *HNRNPUL1 regulates cellular DNA damage tolerance by modulating PCNA ubiquitination*

**作者**: Wang et al. (2020)

**摘要**: 该研究通过免疫共沉淀(Co-IP)和Western blot技术,利用HNRNPUL1特异性抗体验证其与PCNA的相互作用,揭示HNRNPUL1通过调控PCNA单泛素化参与DNA损伤修复的分子机制。

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2. **文献名称**: *Proteomic analysis of HNRNPUL1-containing complexes in breast cancer cells*

**作者**: Smith et al. (2018)

**摘要**: 作者使用HNRNPUL1抗体进行免疫沉淀结合质谱分析,鉴定了其在乳腺癌细胞中与RNA剪接因子及致癌信号通路蛋白(如BRCA1)的相互作用,提示其在癌症中的潜在调控作用。

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3. **文献名称**: *A novel role of HNRNPUL1 in maintaining genomic stability through R-loop resolution*

**作者**: Chen & Lee (2021)

**摘要**: 通过免疫荧光和ChIP实验(使用HNRNPUL1抗体),研究发现HNRNPUL1通过结合R-loop结构调控转录-复制冲突,其缺失导致DNA复制应激和基因组不稳定。

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**注**:以上内容为模拟简化版,实际文献需通过PubMed/Google Scholar检索确认。若需具体文献DOI或链接,建议使用关键词“HNRNPUL1 antibody”或“HNRNPUL1 function”在学术数据库中进一步筛选。

       

背景信息

The HNRNPUL1 antibody is a valuable tool for studying the heterogeneous nuclear ribonucleoprotein U-like 1 (HNRNPUL1) protein, a member of the hnRNP family involved in RNA processing and DNA repair. HNRNPUL1 contains RNA-binding motifs and participates in diverse cellular functions, including transcriptional regulation, mRNA splicing, and maintaining genomic stability. It interacts with proteins like BRCA1. suggesting a role in DNA damage response pathways, particularly homologous recombination repair. Dysregulation of HNRNPUL1 has been linked to cancers, such as hepatocellular carcinoma and breast cancer, where its overexpression may promote tumor progression or metastasis.

Researchers use HNRNPUL1 antibodies in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate its expression patterns, subcellular localization (primarily nuclear, with stress-induced cytoplasmic shifts), and protein-protein interactions. These studies help elucidate its mechanistic roles in disease contexts. Commercially available antibodies are typically raised in rabbits or mice, validated for specificity via knockout controls. Challenges include optimizing experimental conditions due to potential cross-reactivity with homologous hnRNP family members. Ongoing research focuses on HNRNPUL1's potential as a diagnostic biomarker or therapeutic target, particularly in DNA repair-deficient cancers.

       
关键字: HNRNPUL1抗体;HNRNPUL1;HNRNPUL1 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
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