The TLX1 antibody is a crucial tool in biomedical research, primarily used to detect and study the TLX1 protein, also known as HOX11. TLX1 is a transcription factor encoded by the *TLX1* gene, a member of the homeobox gene family involved in embryonic development, particularly in spleen formation and nervous system regulation. Aberrant expression of TLX1 is strongly linked to oncogenesis, notably in T-cell acute lymphoblastic leukemia (T-ALL), where chromosomal translocations (e.g., t(10;14)) lead to its ectopic activation. This dysregulation disrupts normal cellular differentiation, promoting malignant transformation. TLX1 antibodies enable researchers to investigate its expression patterns, subcellular localization, and interactions via techniques like immunohistochemistry, Western blotting, and immunofluorescence. These antibodies are typically monoclonal or polyclonal, generated in hosts such as rabbits or mice, and validated for specificity and sensitivity. Beyond cancer research, TLX1 antibodies contribute to developmental biology studies, exploring its role in organogenesis and stem cell regulation. Their diagnostic potential in identifying TLX1-driven malignancies further underscores their clinical relevance. However, challenges remain in standardizing detection protocols and interpreting TLX1's context-dependent roles, necessitating rigorous validation for experimental accuracy.