ALKBH5抗体,Rabbit Polyclonal ALKBH5 Antibody
  • ALKBH5抗体,Rabbit Polyclonal ALKBH5 Antibody
  • ALKBH5抗体,Rabbit Polyclonal ALKBH5 Antibody
  • ALKBH5抗体,Rabbit Polyclonal ALKBH5 Antibody

ALKBH5抗体;ALKBH5 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-28
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产品详情

中文名称:ALKBH5抗体英文名称:Rabbit Polyclonal ALKBH5 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 7455 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: ALKBH5
2025-05-28 ALKBH5抗体 Rabbit Polyclonal ALKBH5 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 7455 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesABH5; OFOXD; OFOXD1
WB Predicted band size44 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human ALKBH5
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: A549 and Hela cell lysates, Primary antibody: P13720(ALKBH5 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    


           

参考文献

以下是3篇涉及ALKBH5抗体的代表性文献摘要:

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1. **文献名称**:*ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility*

**作者**:Zheng G. et al. (2013)

**摘要**:该研究首次证实ALKBH5作为哺乳动物m6A RNA去甲基酶的功能,通过特异性抗体检测其在睾丸组织中的高表达,并揭示其缺失导致精子形成缺陷及雄性不育。

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2. **文献名称**:*Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation*

**作者**:Zhang C. et al. (2016)

**摘要**:研究利用ALKBH5抗体进行免疫印迹和免疫荧光,证明低氧通过HIF-ALKBH5通路降低m6A水平,促进乳腺癌干细胞特性,揭示了ALKBH5在肿瘤微环境中的调控机制。

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3. **文献名称**:*Dynamic m6A mRNA methylation directs T cell homeostasis*

**作者**:Li H. et al. (2017)

**摘要**:通过ALKBH5抗体进行免疫共沉淀实验,发现ALKBH5介导的m6A修饰动态调控T细胞活化基因的翻译效率,影响T细胞稳态及自身免疫疾病发展。

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如需具体实验抗体信息(如品牌、货号),建议进一步查阅抗体供应商(如Abcam、CST)的产品引用文献。

       

背景信息

The ALKBH5 antibody is a crucial tool for studying the ALKBH5 protein, a member of the AlkB homolog (ALKBH) family of dioxygenases. ALKBH5 specifically catalyzes the demethylation of N6-methyladenosine (m6A), a dynamic and reversible RNA modification pivotal in post-transcriptional gene regulation. Discovered in 2011. ALKBH5 is predominantly localized in the nucleus and plays a key role in RNA metabolism, influencing processes such as mRNA splicing, stability, translation, and nuclear export. Its function in m6A erasure links it to diverse biological pathways, including stem cell differentiation, tumorigenesis, immune responses, and neurological disorders. Dysregulation of ALKBH5 has been implicated in cancers (e.g., glioblastoma, breast cancer), infertility, and metabolic diseases, highlighting its therapeutic potential.

ALKBH5 antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and immunoprecipitation (IP) to detect protein expression, localization, and interactions. High-quality antibodies are validated for specificity (e.g., via knockout controls) and cross-reactivity (e.g., human, mouse). Researchers rely on these antibodies to explore ALKBH5's role in m6A-mediated epigenetic regulation and its association with disease mechanisms. For instance, ALKBH5 inhibitors are being investigated as potential anticancer agents. As m6A research expands, ALKBH5 antibodies remain essential for unraveling RNA modification networks and their impact on cellular physiology and pathology.

       
关键字: ALKBH5抗体;ALKBH5;ALKBH5 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

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