The KIF5C antibody is a crucial tool for studying the kinesin family member 5C (KIF5C), a motor protein involved in intracellular transport. KIF5C belongs to the Kinesin-1 family (also known as conventional kinesin), which includes three isoforms (KIF5A, KIF5B, KIF5C) encoded by distinct genes. Among these, KIF5C is predominantly expressed in neurons and plays a vital role in anterograde transport along microtubules, facilitating the movement of cargoes such as organelles, vesicles, and mRNAs within axons and dendrites. Its function is critical for neuronal development, synaptic plasticity, and maintenance.
Antibodies targeting KIF5C enable researchers to detect and localize the protein in various experimental models, including Western blotting, immunohistochemistry, and immunofluorescence. These tools are essential for investigating KIF5C's expression patterns, interactions, and regulatory mechanisms. Dysregulation of KIF5C has been implicated in neurological disorders, such as Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), and hereditary spastic paraplegia, where impaired axonal transport contributes to pathogenesis. Additionally, studies using KIF5C antibodies have shed light on its role in neurodevelopment and response to injury. Specificity validation is critical, as KIF5C shares structural homology with other KIF5 isoforms. Overall, KIF5C antibodies are indispensable for advancing understanding of neuronal transport biology and related diseases.