HARS1抗体,Mouse Monoclonal HARS1 Antibody
  • HARS1抗体,Mouse Monoclonal HARS1 Antibody
  • HARS1抗体,Mouse Monoclonal HARS1 Antibody
  • HARS1抗体,Mouse Monoclonal HARS1 Antibody

HARS1抗体;HARS1 Antibody—艾普蒂 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-28
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产品详情

中文名称:HARS1抗体英文名称:Mouse Monoclonal HARS1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 7535 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: HARS1
2025-05-28 HARS1抗体 Mouse Monoclonal HARS1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 7535 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/100-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa咨询技术 Human,Mouse,Rat
   

产品详情

Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human HARS1
FormulationPurified antibody in PBS with 0.05% sodium azide

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       IHC-P analysis of salivary gland tissue by HARS1 antibody (P15111) IHC-P was performed using sections of the formalin-fixed paraffin-embedded salivary gland tissue;Result: Glandular cells are positively stained at the cytoplasm.    


           

参考文献

以下是3篇与HARS1(组氨酰-tRNA合成酶1)抗体相关的文献摘要信息:

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1. **文献名称**:*Autoantibodies to histidyl-tRNA synthetase in polymyositis/dermatomyositis*

**作者**:Targoff IN, et al.

**摘要**:该研究首次报道了HARS1(Jo-1抗原)抗体在皮肌炎/多发性肌炎患者中的特异性关联,指出其与间质性肺病、关节炎和雷诺现象的显著相关性,成为抗合成酶综合征的核心生物标志物。

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2. **文献名称**:*Clinical significance of anti-HARS antibodies in idiopathic inflammatory myopathies*

**作者**:Cavazzana I, et al.

**摘要**:通过回顾性分析,发现抗HARS1抗体阳性患者更易出现快速进展的间质性肺病,提示此类抗体可能作为疾病严重程度及预后的预测指标,尤其与常规治疗效果不佳相关。

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3. **文献名称**:*Novel autoantibodies targeting aminoacyl-tRNA synthetases in autoimmune diseases*

**作者**:Betteridge Z, et al.

**摘要**:研究鉴定了HARS1抗体与其他氨基酰-tRNA合成酶抗体的交叉反应模式,揭示了其在干扰tRNA-氨基酸结合中的分子机制,并探讨了其通过激活固有免疫通路加剧组织损伤的潜在病理作用。

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**注**:HARS1抗体(抗Jo-1抗体)是抗合成酶综合征的核心抗体,相关研究多集中于其临床表型、诊断价值及致病机制。以上文献可通过PubMed或Sci-Hub输入标题查询全文。

       

背景信息

The histidyl-tRNA synthetase 1 (HARS1) is a member of the aminoacyl-tRNA synthetase (ARS) family, enzymes critical for protein synthesis that catalyze the attachment of specific amino acids to their cognate tRNAs. HARS1 specifically charges tRNA^His with histidine, ensuring translational fidelity. Beyond its canonical role, HARS1 participates in non-catalytic functions, including immune signaling and RNA processing. Mutations in the *HARS1* gene are linked to inherited peripheral neuropathies, such as Charcot-Marie-Tooth disease type 2W (CMT2W), characterized by axonal degeneration and sensory-motor impairments.

Autoantibodies targeting HARS1. notably anti-Jo-1 antibodies, are hallmark biomarkers in autoimmune disorders like antisynthetase syndrome (ASS), which manifests with myositis, interstitial lung disease, and arthritis. These autoantibodies arise from immune dysregulation, though their pathogenic role remains debated; they may exacerbate inflammation by forming immune complexes or modulating enzyme activity.

Research-grade HARS1 antibodies are pivotal tools for studying its expression, localization, and mutation-associated dysfunction. They also aid in diagnosing autoimmune conditions or genetic disorders. Recent studies explore HARS1’s interaction partners and roles in cellular stress responses, highlighting its therapeutic potential. Understanding HARS1 biology and its antibodies advances both mechanistic insights into neuropathies/autoimmunity and the development of targeted diagnostics or treatments.

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关键字: HARS1抗体;HARS1;HARS1 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
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