SERPINC1抗体;SERPINC1 Antibody—艾普蒂

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     Lane 1: plasma ;  Lane 2: SERPINC1 immunoprecipitated from plasma by P15268 ;  Lane 3: The same as Lane 2 but use IgG isotype control antibody ;Result: P15268 can immunoprecipitate SERPINC1;    

  
  

SERPINC1. also known as antithrombin III (ATIII), is a serine protease inhibitor that plays a critical role in regulating blood coagulation. It inactivates thrombin and other clotting factors (e.g., Factor Xa) by forming stable complexes, thereby preventing excessive clot formation. SERPINC1 deficiency, whether hereditary or acquired, is linked to an increased risk of venous thromboembolism (VTE). Hereditary mutations in the SERPINC1 gene can cause type I (quantitative) or type II (qualitative) deficiencies, both associated with thrombotic disorders.

Antibodies targeting SERPINC1 are essential tools in research and diagnostics. They are used to quantify antithrombin levels in plasma via ELISA or immunoturbidometric assays, aiding in the diagnosis of thrombophilia. In research, these antibodies help study SERPINC1's structure-function relationships, interactions with heparin (which enhances its activity), and mechanisms underlying thrombosis. Monoclonal antibodies may also have therapeutic potential, such as in developing antithrombin replacement therapies for deficient patients. However, autoantibodies against SERPINC1 are rare but can cause acquired deficiencies, as seen in certain autoimmune conditions.

Overall, SERPINC1 antibodies bridge clinical diagnostics, pathophysiology studies, and therapeutic innovation in coagulation disorders.