DBN1抗体;DBN1 Antibody—艾普蒂 新品

+ +

•  

   

     Lane 1: 15 µg of SH-SY5Y lysate;  Lane 2: 15 µg of rat brain;  Lane 3: 15 µg of mouse brain;Result: P15503 can detect DBN1 by Western blotting;    

  
  

•  

   

     Lane 1: Mouse brain tissue lysate ;  Lane 2: DBN1 immunoprecipitated from mouse brain tissue lysate by P15503 ;  Lane 3: The same as Lane 2 but use IgG isotype control antibody ;Result: P15503 can immunoprecipitate DBN1;    

  
  

•  

   

     IHC-P analysis of brain tissue by DBN1 antibody (P15503) IHC-P was performed using sections of the formalin-fixed paraffin-embedded brain tissue;Result: Neuropil is positively stained.    

  
  

DBN1 (Drebrin-like protein) is a cytoskeletal-associated protein that plays a critical role in regulating actin dynamics, particularly in neuronal and cancer cells. It shares structural homology with drebrin, a protein essential for synaptic plasticity, and is involved in processes such as cell migration, adhesion, and morphogenesis. DBN1 is highly expressed in the brain, where it contributes to dendritic spine formation and neuronal network organization. In cancer biology, DBN1 is implicated in tumor metastasis by promoting invadopodia formation, facilitating extracellular matrix degradation, and enhancing invasive cell behavior. Its overexpression has been linked to poor prognosis in cancers like glioblastoma and hepatocellular carcinoma.

DBN1 antibodies are essential tools for studying these biological processes. They enable the detection and localization of DBN1 in tissues and cultured cells through techniques like Western blotting, immunofluorescence, and immunohistochemistry. Researchers also use these antibodies to investigate DBN1's functional roles via knock-down/knock-out experiments or inhibition studies. Commercially available DBN1 antibodies are typically raised against specific epitopes, such as the N-terminal or coiled-coil domains, and require validation for species cross-reactivity (human, mouse, rat) and application-specific suitability. Recent studies employing DBN1 antibodies have advanced understanding of neurodevelopmental disorders and cancer mechanisms, highlighting its dual role in neural homeostasis and pathological cell invasion.