TSC1抗体;TSC1 Antibody—艾普蒂

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     Western blot analysis using TSC1 mouse mAb against  HEK-293 lysate    

  
  

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     Lane 1: HEK-293 lysate ;  Lane 2: TSC1 immunoprecipitated from HEK-293 lysate by P15546 ;  Lane 3: The same as Lane 2 but use IgG isotype control antibody ;Result: P15546 can immunoprecipitate TSC1;    

  
  

The TSC1 antibody is a crucial tool in studying the TSC1 protein, encoded by the tuberous sclerosis complex 1 (TSC1) gene. TSC1. along with TSC2. forms a heterodimeric complex that acts as a key regulator of the mTOR (mechanistic target of rapamycin) signaling pathway. This pathway is central to cellular growth, proliferation, and metabolism. Mutations in TSC1 are linked to tuberous sclerosis complex (TSC), a genetic disorder characterized by benign tumor formation in multiple organs, including the brain, kidneys, and skin.

TSC1 antibodies are widely used in research to detect and quantify TSC1 protein expression in tissues or cultured cells. They enable investigations into the protein’s localization, interaction with TSC2. and its role in mTOR pathway suppression under normal and disease conditions. These antibodies are essential for techniques like Western blotting, immunohistochemistry, and immunofluorescence.

In disease models, TSC1 antibodies help elucidate molecular mechanisms underlying TSC-related pathologies and mTOR hyperactivation in cancers or neurological disorders. They also aid in evaluating therapeutic interventions targeting the mTOR pathway. Due to TSC1’s tumor-suppressive function, such antibodies are valuable in both basic research and clinical diagnostics, offering insights into disease progression and potential biomarkers. Their specificity and reliability are critical for advancing understanding of cellular homeostasis and developing targeted therapies.