WDR59抗体;WDR59 Antibody—艾普蒂 新品

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     Western blot analysis using WDR59 mouse mAb against  Jurkat lysate    

  
  

The WDR59 antibody is a research tool designed to detect and study the WD repeat-containing protein 59 (WDR59), a component of the GATOR2 complex in the mTORC1 signaling pathway. WDR59 contains conserved WD40 repeat motifs, which mediate protein-protein interactions, and plays a role in nutrient sensing by regulating mTORC1 activity. As part of GATOR2. WDR59 interacts with other subunits like WDR24 and MIOS to inhibit the upstream negative regulator GATOR1. thereby activating mTORC1 under amino acid-sufficient conditions. Dysregulation of this pathway is linked to cancer, metabolic disorders, and neurodegenerative diseases.

WDR59 antibodies are typically developed in host species (e.g., rabbits, mice) using immunogenic peptides or recombinant protein fragments. They enable applications such as Western blotting, immunoprecipitation, and immunofluorescence to analyze WDR59 expression, localization, and interactions in cell lines or tissues. Commercial antibodies often undergo validation for specificity via knockout controls or siRNA knockdown. However, variability in antibody performance across studies has been reported, emphasizing the need for rigorous validation. Research using WDR59 antibodies has expanded insights into its tissue-specific roles, post-translational modifications, and potential therapeutic targeting in diseases like cancer. Current challenges include elucidating its precise molecular mechanisms and resolving discrepancies in pathway models.