PAX7抗体,Rabbit Monoclonal PAX7 Antibody
  • PAX7抗体,Rabbit Monoclonal PAX7 Antibody
  • PAX7抗体,Rabbit Monoclonal PAX7 Antibody
  • PAX7抗体,Rabbit Monoclonal PAX7 Antibody

PAX7抗体;PAX7 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-29
QQ交谈 微信洽谈

产品详情

中文名称:PAX7抗体英文名称:Rabbit Monoclonal PAX7 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 7974 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: PAX7
2025-05-29 PAX7抗体 Rabbit Monoclonal PAX7 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 7974 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/20-1/100 Human,Mouse,Rat
Elisa咨询技术 Human,Mouse,Rat
   

产品详情

AliasesPaired box protein Pax-7; HuP1; PAX7; HUP1;;PAX7
WB Predicted band sizeCalculated MW: 55 kDa ; Observed MW: 57 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human PAX7
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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       All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    


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       All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    


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       All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    


           

参考文献

以下是关于PAX7抗体的3篇参考文献示例(内容基于典型研究方向,具体文献需根据实际数据库检索确认):

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1. **文献名称**:*Pax7 is required for the specification of myogenic satellite cells*

**作者**:Seale, P., Sabourin, L.A., Girgis-Gabardo, A., Mansouri, A., Gruss, P., Rudnicki, M.A.

**摘要**:该研究通过免疫组化使用PAX7抗体,首次证明PAX7蛋白在肌肉卫星细胞中特异性表达,并揭示其在维持肌肉干细胞静息状态和激活分化中的关键作用。

2. **文献名称**:*A division of labor between Pax7 and Lbx1 in sensory nervous system development*

**作者**:Basch, M.L., Bronner-Fraser, M., García-Castro, M.I.

**摘要**:研究利用PAX7抗体标记神经嵴细胞,发现PAX7与Lbx1在感觉神经元分化中的协同作用,为神经嵴发育的分子机制提供了新见解。

3. **文献名称**:*PAX7 expression in rhabdomyosarcoma: a biomarker for embryonic subtype*

**作者**:Williamson, D., Missiaglia, E., de Reyniès, A., et al.

**摘要**:通过Western blot和免疫组化分析,发现PAX7抗体在胚胎型横纹肌肉瘤中高表达,提示PAX7可作为该亚型肿瘤的诊断标志物及潜在治疗靶点。

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**备注**:以上文献为示例,实际引用时请通过PubMed或Google Scholar核实具体信息,并补充DOI或期刊卷期页码。若需实验方法学文献,可搜索对比PAX7抗体特异性的研究(如:*"Characterization of PAX7 antibody specificity in skeletal muscle development"*)。

       

背景信息

The PAX7 antibody is a valuable tool in developmental biology and cancer research, targeting the paired box protein PAX7—a transcription factor crucial for embryogenesis. PAX7 belongs to the PAX family of proteins characterized by a conserved paired box DNA-binding domain and a transcriptional activation domain. It plays a pivotal role in neural crest development, skeletal muscle stem cell (satellite cell) specification, and maintenance. During muscle regeneration, PAX7 is essential for satellite cell proliferation and differentiation, making its antibody a key reagent for identifying and studying muscle stem cells in tissues or cultures.

In research, PAX7 antibodies are widely used in techniques like immunohistochemistry, immunofluorescence, and flow cytometry to localize and quantify PAX7-expressing cells. Commercially available monoclonal and polyclonal variants vary in specificity, often validated across species (human, mouse, rat). Aberrant PAX7 expression is linked to cancers such as alveolar rhabdomyosarcoma and neuroblastoma, where it may drive oncogenesis or indicate poor prognosis. However, its role remains context-dependent; in melanoma, PAX7 downregulation correlates with metastasis.

Researchers also utilize PAX7 antibodies to explore regenerative medicine strategies and tumor heterogeneity. Cross-reactivity with other PAX family members (e.g., PAX3) requires careful validation to ensure experimental accuracy. Overall, PAX7 antibodies bridge mechanistic insights into developmental pathways and disease mechanisms, with diagnostic and therapeutic potential.

       
关键字: PAX7抗体;PAX7;PAX7 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
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