**Background of GC1qR Antibody**
The gC1qR (globular head domain of C1q receptor), also known as p32/HABP1. is a multifunctional protein localized predominantly in mitochondria but also expressed on the cell surface. It interacts with diverse ligands, including the globular regions of complement component C1q, viral proteins, and extracellular matrix components, playing roles in immune regulation, infection, and cellular processes like apoptosis and inflammation.
GC1qR antibodies are tools used to detect and study this protein’s expression, localization, and function. Research highlights its involvement in pathological conditions: it serves as a receptor for pathogens (e.g., HIV, hepatitis viruses), contributes to autoimmune diseases (e.g., lupus) by enhancing complement activation, and is overexpressed in cancers, promoting tumor progression and metastasis. Antibodies against GC1qR help elucidate its role in viral entry, immune evasion, and cancer biology, making them valuable in diagnostic and therapeutic research.
Recent studies also explore GC1qR as a potential therapeutic target. Inhibiting its interactions with pathogens or modulating complement activity could mitigate disease progression. However, its dual intracellular/extracellular roles and tissue-specific expression necessitate careful interpretation in experimental models. GC1qR antibodies thus remain critical for unraveling its complex biology and translational applications.